Comparative study of using different levels of positive endexpiratory pressure with dexmedetomidinebased sedation regimen after offpump coronary artery bypass grafting

doi:10.3969/j.issn.10073205.2016.02.015

Journal of Hebei Medical University

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Comparative study of using different levels of positive endexpiratory pressure with dexmedetomidinebased sedation regimen after offpump coronary artery bypass grafting

DepartmentofAnesthesiology , theCentralHospitalofCangzhouCity ,
HebeiProvince , Cangzhou 061000 , China

Online:2016-02-25 Published:2016-04-27

Abstract

Abstract: ] Objective Toevaluatetheuseofdexmedetomidine-basedsedationregimenon
differentlevelsofpositiveend-expiratorypressure ( PEEP ) afteroff-pumpcoronaryarterybypass
grafting ( OPCABG ) .Methods Thisisanopenprospectivestudy with60consecutiveadult
patientsafterOPCABGontheuseofdexmedetomidine-basedsedationregimenundervolume-
controlledmechanicalventilation ( VCV ) withdifferentPEEP , dividedintothreegroups ( Group
A : PEEP= 0cmH 2 O , GroupB : PEEP= 5cmH 2 O , GroupC : PEEP= 10cmH 2 O ) .Results
Fromthepointofweaningfrom mechanicalventilationuntil12hoursafterOPCABG , compared
withGroupAandB , theapplieddoseofdexmedetomidinewasincreased ( P <0.05 ), average
mechanicalventilationwasshorten ( P <0.05 ), durationinICUandhospitalwasshorten ( P <
0.05 ), andPaO 2 atpostoperative12hand24hwasincreased ( P <0.05 ) inGroupC.Conclusion
PEEPat10cmH 2 Ocansignificantlyimproveprognosis.HigherlevelofPEEPrequired more
dexmedetomidine , but the patients were associated with shorter duration of mechanical
ventilationinpostoperativeOPCABGpatients.

Key words: coronary artery bypass, off-pump , positive-pressure respiration ;dexmedetomidine

SUN Wen-bo,ZHANGLi-min,WUChun-ling,LIRui. Comparative study of using different levels of positive endexpiratory pressure with dexmedetomidinebased sedation regimen after offpump coronary artery bypass grafting[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.02.015.

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Comparative study of using different levels of positive endexpiratory pressure with dexmedetomidinebased sedation regimen after offpump coronary artery bypass grafting

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