Objective To explore the predictive effectiveness of serum thymidine kinase 1 (TK-1) combined with heat shock protein 90α (Hsp90α) for curative effect of high-intensity focused ultrasound (HIFU) ablation in liver cancer. 

Methods A total of 150 patients with liver cancer undergoing HIFU ablation in the hospital between May 2022 and October 2024 were enrolled. According to different curative effect, they were divided into complete ablation group (n=120) and residual group (n=30). The levels of serum TK-1, Hsp90α and alpha-fetoprotein (AFP) in the two groups were detected and compared before surgery. The predictive effectiveness of the three indexes detected alone or in combination for curative effect of HIFU ablation in liver cancer was analyzed by receiver operating characteristic (ROC) curves, and influencing factors of the curative effect were analyzed by multivariate Logistic regression analysis. 
Results The levels of serum TK-1, Hsp90α and AFP in residual group were higher than those in complete ablation group ［(5.50±1.11) pmol/L vs. (4.28±0.95) pmol/L, (134.28±14.22) μg/L vs. (116.60±13.78) μg/L, (42.17±10.93) μg/L vs. (29.56±9.65) μg/L; P＜0.05］. There was significant difference in China Liver Cancer Staging (CNLC) between the two groups (P＜0.05). ROC curve analysis showed that area under the curve (AUC) of serum TK-1 combined with Hsp90α for predicting the curative effect of HIFU ablation was 0.912 ［95%CI: 0.851-0.974］, which was greater than that of single index or AFP (TK-1: 0.791, Hsp90α: 0.802, AFP: 0.799). AUC of TK-1 combined with Hsp90α and AFP for predicting the curative effect was 0.925 ［95%CI: 0.876-0.974］, which was greater than that of single index (Tk-1:0.791, Hsp90α : 0.802, AFP: 0.799). Multivariate Logistic regression analysis showed that CNLC stage Ⅰb (OR=2.004, P=0.001), TK-1＞5.09 pmol/L (OR=2.492, P＜0.001) and Hsp90α >125.00 μg/L (OR=2.509, P＜0.001) were independent risk factors affecting curative effect of HIFU ablation. 
Conclusion Serum TK-1, Hsp90α and AFP all can predict the curative effect of HIFU ablation in liver cancer, and predictive effectiveness of serum TK-1 combined with Hsp90α is higher than that of AFP. 

Objective To investigate the impact of the miR-106a-5p/programmed death-ligand 1 (PD-L1) axis on the malignant biological behavior of nasopharyngeal carcinoma (NPC) cells and its molecular mechanism. 
Methods The expression levels of miR-106a-5p and PD-L1 mRNA in the NPC cell line HNE1 and immortalized normal nasopharyngeal epithelial cell line NP69 were measured using quantitative real-time PCR (RT-qPCR), and PD-L1 protein expression was assessed by Western blotting. A dual-luciferase reporter assay was performed to verify the direct regulatory relationship between miR-106a-5p and PD-L1. HNE1 cells were transfected with miR-106a-5p mimics, inhibitors, si-PD-L1, or PD-L1 overexpression plasmids. Cell proliferation was evaluated by the CCK-8 assay, while cell migration and invasion were assessed using scratch assays and Transwell assays, respectively. 
Results The expression levels of miR-106a-5p and PD-L1 were significantly higher in NPC cells than in normal nasopharyngeal epithelial cells (miR-106a-5p: P=0.001，PD-L1-mRNA: P=0.012, PD-L1-protein: P=0.008). The dual-luciferase reporter assay confirmed that PD-L1 was a direct target of miR-106a-5p. miR-106a-5p significantly increased the mRNA and protein levels of PD-L1 (P=0.010; P=0.037), whereas the miR-106a-5p inhibitor markedly suppressed PD-L1 expression (P＜0.001). Overexpression of PD-L1 led to a significant upregulation of miR-106a-5p (P＜0.05), and knockdown of PD-L1 significantly reduced miR-106a-5p levels (P＜0.05). Overexpression of either miR-106a-5p or PD-L1 significantly enhanced the proliferation, invasion and migration of HNE1 cells (bothP＜0.05), while knockdown of either PD-L1 or miR-106a-5p reversed these effects (both P＜0.05). Conversely, knockdown of miR-106a-5p or PD-L1 significantly inhibited cell proliferation, invasion and migration, and overexpression of either PD-L1 or miR-106a-5p could reverse this inhibition (both P＜0.05). 
Conclusion There is a positive feedback regulation between miR-106a-5p and PD-L1, which promotes the proliferation, migration, and invasion of NPC cells.

Objective The mechanical stability of the osteotomy site significantly decreases in patients with Takeuchi type Ⅱ hinge fractures after medial open wedge high tibial osteotomy (MOWHTO), which may affect prognosis. The purpose of this study is to explore the effect of auxiliary fixation system (AFS) supplemented on the basis of the original internal fixation on the mechanical stability of the osteotomy site, and to provide a reference for the treatment and rehabilitation of type Ⅱ hinge fractures. 
Methods The MOWHTO finite element models A and B, representing intact hinges and Takeuchi Ⅱ hinge fractures, were established using bone data from CT scans of the human lower extremities and incorporating TomoFix plates and screws. On the basis of model B, AFS was supplemented to construct model C. Different axial compressive loads were applied above the tibial plateau of the models, replicating states ranging from sitting to standing and walking. Additionally, torsional loads were applied to mimic rotational state. The maximum stress on the internal fixator, as well as the maximum displacement at the medial osteotomy site and the lateral hinge position under these conditions, was measured to evaluate the changes in mechanical stability at the osteotomy site. 
Results From the sitting to the standing state, compared with model A, the maximum stresses of the plates in models B and C increased by 178.3% and 95.9% respectively, the maximum displacement at the medial osteotomy site increased by 33.2% and 29.7% respectively, and the maximum displacement at the lateral hinge position increased by 51.0% and 43.7% respectively. The maximum stresses of the plate in the walking state increased by 113.1% and 91.9% respectively, and the maximum displacement at the medial osteotomy site increased by 17.2% and 13.8% respectively. The maximum displacement at the lateral hinge position increased by 389.4% and 385.1% respectively, and the maximum stresses of the plate under torsional load increased by 261.4% and 122.0% respectively. The maximum displacement at the medial osteotomy site increased by 362.6% and 242.1% respectively, and the maximum displacement at the lateral hinge position increased by 338.8% and 204.7% respectively. Compared with model A, the maximum stress of the plate in models B and C increased under various states, and the increase of model B was more obvious. Compared with the sitting to standing and walking states, the difference of the maximum stress increase of the plate between models B and C was the largest (139.4%) under the torsional load state. 
Conclusion This study demonstrates that type Ⅱ hinge fractures may result in a reduction of stability at the osteotomy site after MOWHTO, particularly during transitions from sitting to standing and twisting states. During the operation, the stability around the hinges needs to be strengthened, and corresponding actions should be performed under protective conditions after the operation. The supplemented AFS can enhance the stability of the osteotomy site and distribute the stress on the internal fixator. Theoretically, this approach could decrease the incidence of internal fixator failure, postoperative alignment deviation, and nonunion at the osteotomy site. Compared with the original internal fixation alone, it allows for earlier partial weight-bearing, which facilitates rapid recovery and minimizes complications. While AFS appears promising for the treatment of hinge fractures, further biomechanical investigations are warranted to confirm its efficacy. 

Objective To establish a heart failure (HF) cell model and to investigate the role of euchromatic histone-lysine N-methyltransferase 2 (G9a) in the progression of HF by regulating the expression of brain-derived neurotrophic factor （BDNF） through H3K9me2 in cardiomyocytes of H9C2 rats. 
Methods H9C2 rat cardiomyocytes were cultured, passed, gene transfected and oxygen glucose deprivation (OGD)-treated to establish the HF cell model. RT-qPCR and Western blot were used to detect the expression of G9a mRNA in the OGD-treated HF cell model and control group. The expression of BDNF mRNA in OGD-treated HF cell model after G9a knockout was detected. The expression of OGD-treated H9C2 and OGD-treated H3K9me2 after G9a knockout was detected in H9C2 cells. 
Results The expression of G9a was up-regulated in OGD-treated cell models. The apoptosis and injury of H9C2 rat cardiomyocytes after OGD treatment were inhibited by G9a gene deletion. Silencing G9a promoted the expression of BDNF by inhibiting H3K9me2 modification of BDNF promoter. Silencing BDNF partially reversed sh-G9a by activating the TrkB signaling pathway to reduce cardiomyocyte apoptosis and damage. 
Conclusion In HF model of H9C2 rat cardiomyocytes, G9a regulates the expression of BDNF through H3K9me2, and is involved in the development of HF, which can provide ideas for clinical research on HF markers.

Objective To investigate the effects of different neurokinin-1 receptor antagonists ［aprepitant (APT), netupitant］ on the pharmacokinetics of albumin-bound paclitaxel in rats. 
Methods Thirty-two Sprague-Dawley (SD) rats were randomly divided into four groups (n=8), and then gavaged with normal saline, APT suspension, netupitant/palonosetron (NEPA) compound preparation suspension, and palonosetron (PALO) suspension, respectively. One hour afterwards, taxol and platinum-based chemotherapy regimen (TP) was sequentially given to therats in the four groups. Albumin-bound paclitaxel and cisplatin were sequentially injected into the tail vein of the rats in the four groups. After administration, blood was taken from the canthus of the eyes. The concentration of paclitaxel in the plasma of the rats was determined, and the differences of pharmacokinetic parameters in each group were compared. 
Results Compared with the TP group, the area under the plasma concentration-time curve (AUC), namely AUC0-t and AUC0 -∞, of paclitaxel in the plasma of rats treated with APT (TP group vs. TP+APT group) increased by 25.78% (P=0.005) and 24.92% (P=0.006), respectively, while apparent volume of distribution (Vd) and clearance(CL) decreased by 29.25% (P=0.001) and 21.19% (P=0.003), respectively, with statistical differences. The maximum plasma concentration (Cmax), AUC0-t, AUC0-∞ of paclitaxel in plasma of rats in the combination treatment group (TP group vs. TP + NEPA group) increased by 28.33% (P＜0.001), 42.46% (P＜0.001), 40.26% (P＜0.001), respectively， while Vd and CL decreased by 35.40% (P＜0.001), and 29.85% (P＜0.001), respectively, with statistical differences. The Vd of paclitaxel in rat plasma decreased by 19.57% (P=0.016) after combined use of PALO (TP group vs. TP+PALO group), with statistical difference, and other pharmacokinetic parameters had no statistical difference. 
Conclusion PALO has no significant effect on the pharmacokinetics of albumin-bound paclitaxel, while APT and netupitant can increase the exposure of albumin-bound paclitaxel in rats, and netupitant has a greater effect on the exposure of albumin-bound paclitaxel in rats.Therefore, in clinical practice, attention should be paid to monitoring the blood concentration of albumin-bound paclitaxel when it is used in combination with APT or netupitant.

Objective To investigate the absorption and safety of resveratrol  self-microemulsion in rats. 
Methods The optimal formula for resveratrol self-microemulsion was chosen and determined using a pseudo-ternary phase diagram. The quality characteristics of the self-microemulsion were evaluated in terms of particle size, morphology, dissolution, and stability. The intestinal absorption of resveratrol was investigated through in vivo intestinal absorption tests, and the oral bioavailability of the self-microemulsion was assessed using pharmacokinetic tests. The safety of self-microemulsion was evaluated through an acute oral toxicity test in mice. 
Results The optimal formula for the resveratrol self-microemulsion included 22 g triacetate, 27 g polyoxyethylene castor oil, 13.5 g polyoxyethylene hydrogenated castor oil, 37.8 g isopropyl alcohol, and 3.5 g resveratrol. This mixture had a uniform particle size (14.528±0.314) nm and good stability. Compared with the suspension phase, the absorption rate constant (Ka) and apparent distribution coefficient (Papp) of the self-microemulsion were (2.131±0.576) times and (2.382±0.688) times respectively,  the time to reach peak blood concentration and mean residence time were (3.272±0.403) times and (2.531±0.569) times respectively, and both the peak concentration and the area under the curve were (3.588±0.454) times and (10.985±2.997) times respectively. No toxic reactions or obvious weight changes were observed in the suspension group, microemulsion adjuvant group, or self-microemulsion group (P＞0.05). 
Conclusion The self-microemulsion effectively improves the stability of resveratrol, significantly enhances its intestinal absorption and oral bioavailability, and has good safety, providing an experimental basis for expanding the clinical application of resveratrol. 

Objective To explore the relationship between expression levels of secreted phospholipase A2 (sPLA2), ischemic modified albumin (IMA), and ubiquitin carboxy terminal hydrolases L1 (UCH-L1) and poor prognosis in patients with acute cerebral infarction (ACI) and their predictive value. 
Methods A total of 300 patients with ACI admitted to Fengfeng General Hospital of Huabei Medical and Health Group in Handan City, Hebei Province, between January 2021 and January 2023 were randomly selected as research subjects. At 3 months after discharge, the Modified Rankin Scale (mRS) was utilized to evaluate prognosis, and the expression levels of sPLA2, UCH-L1, and IMA were measured. Among them,150 patients were selected based on their order of admission and subsequently categorized according to mRS assessment results. Patients demonstrating favorable outcomes (scores of 0-2) constituted the control group, while those exhibiting unfavorable outcomes (scores of 3-6) formed the research group. Differences in expression levels of sPLA2, UCH-L1, and IMA between the research group and control group were compared using receiver operating characteristic (ROC) curves, to analyze the predictive efficacy of these biomarkers for poor prognosis in ACI patients as well as determining their cutoff values. The remaining cohort of 150 ACI patients was divided into high-expression and low-expression groups for sPLA2, UCH-L1, and IMA based on established cutoff values respectively. Differences in mRS scores among these biomarker groups were then compared. 
Results A total of 80 patients with good prognosis (0-2 points) were included in the control group, and 70 patients with poor prognosis (3-6 points) were included in the research group. Compared with the control group, sPLA2 ［(14.77±3.27) μg/L vs. (9.81±3.09) μg/L］, UCH-L1 ［(0.87±0.23)μg/L vs. (0.56±0.18) μg/L］ and IMA ［(51.15±9.21) kU/L vs. (36.62±8.65) kU/L］ were significantly increased in the research group (t=9.545, 9.247, 9.958, P＜0.001). The area under the curve (AUC) of sPLA2, UCH-L1 and IMA in predicting poor prognosis of ACI patients was 0.842, 0.829 and 0.833, respectively, the sensitivity was 81.43%, 81.43% and 80.00%, respectively, and the specificity was 82.50%, 90.00% and 88.75%, respectively. The low expression of sPLA2, UCH-L1 and IMA was found in 81, 90 and 79 patients, respectively, while the high expression of sPLA2, UCH-L1 and IMA was found in 69, 60 and 71 patients, respectively. Compared with sPLA2, UCH-L1 and IMA high expression groups, the mRS scores of sPLA2 low expression group ［(4.70±1.09) scores vs. (1.27±1.06) scores］, UCH-L1 low expression group ［(4.48±1.33) scores vs. (1.76±1.62) scores］ and IMA low expression group ［(4.56±1.20) scores vs. (1.30±1.18) scores］ were significantly decreased (t=19.425, 11.235, 16.709, P＜0.001). 
Conclusion sPLA2, UCH-L1 and IMA in ACI patients with poor prognosis are significantly increased and closely related. Therefore, sPLA2, UCH-L1 and IMA can be used as sensitive indicators to predict the prognosis of ACI patients. 

Objective To investigate the predictive value of atherogenic index of plasma (AIP) combined with blood uric acid/high-density lipoprotein cholesterol ratio (UHR) in the development of early diabetic peripheral neuropathy (DPN) in patients with type 2 diabetes mellitus (T2DM). 
Methods In total,314 patients with suspected DPN were selected from the Outpatient Department of Endocrinology, Hebei Provincial Hospital of Traditional Chinese Medicine from August 2022 to August 2023, and underwent neurophysiological examination after admission to the hospital. According to the results of the examination, 173 patients were finally diagnosed with DPN (DPN group), and the remaining 141 patients who were not diagnosed with DPN were assigned to the NDPN group. The general clinical data and nerve conduction velocity of the patients were collected, and the values of AIP and UHR were calculated. Spearman correlation analysis was performed to analyze the correlation between AIP, UHR and nerve conduction velocity, and logistic regression analysis was performed to analyze the influencing factors of DPN. The receiver operating characteristic (ROC) of AIP and UHR alone and in combination was plotted to predict the occurrence of early DPN, and the predictive efficacy was evaluated. 
Results Comparison of gender, age and duration of diabetes mellitus between the two groups showed no significant difference (P＞0.05). Fasting blood glucose, glycosylated hemoglobin, total cholesterol, and low-density lipoprotein cholesterol  were not significantly elevated in the DPN group compared with the NDPN group, showing no significant difference (P＞0.05), while nerve conduction velocity, triacylglycerol, high-density lipoprotein cholesterol,serum uric acid, AIP, and UHRshowed significant difference (P＜0.05). Spearman correlation analysis showed that AIP and UHRwere negatively correlated with nerve conduction velocity (P＜0.05). Logistic regression analysis showed that age (OR=1.038, 95%CI: 1.013-1.064), duration of disease (OR=1.122,95%CI: 1.012-1.244), AIP (OR=1.680,95%CI: 1.384-2.039), and UHR (OR=1.006,95%CI: 1.003-1.008) were independent risk factors for DPN (P＜0.05). The results of ROC curve analysis showed that the area under curve (AUC) of AIP and UHR alone and in combination for predicting early DPN was 0.731 (95%CI: 0.676-0.785), 0.727 (95%CI: 0.671-0.783), 0.774 (95%CI: 0.722-0.826), respectively, with cut-off values of 2.25, 337.36, and 0.56, respectively, sensitivity of 63.6%, 65.3%, and 70.5%, and specificity of 74.5%, 72.3%, and 75.9%, respectively. 
Conclusion Both AIP and UHR are independent risk factors for inducing early DPN, and the combined application of the two has a higher value in predicting early DPN compared with a single indicator. 

Objective To explore the correlation between bone mineral density (BMD), bone metabolism indexes and sarcopenia in patients with rheumatoid arthritis (RA) of different disease activity, so as to provide a theoretical basis for clinical practice. 
Methods A total of 97 RA patients who were treated in the Third People′s Hospital of Chengdu from December 2021 to December 2024 were selected and divided into the research group and the control group according to the occurrence of sarcopenia. Some inflammatory indexes, BMD and bone metabolism indexes of the patients were recorded. The RA of different severity (mild activity, moderate activity, severe activity) was evaluated according to DAS28 score. 
Results The prevalence rates of sarcopenia in RA patients with mild, moderate and severe activity were 42.86%, 62.22% and 80.64% respectively, with significant differences (P＜0.001). Correlation analysis showed that tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were positively correlated with sarcopenia (r=0.381, 0.615, P＜0.001), while lumbar BMD (T12-L2), serum bone alkaline phosphatase (BALP), β-C-terminal telopeptide of type I collagen (β-CTX), procollagen type Ⅰ N-terminal propeptide (PINP), N-terminal osteocalcin (N-MID), 25-hydroxyvitamin D3 ［25(OH)D3］ and parathyroid hormone (PTH) were negatively correlated with sarcopenia (r=-0.711, -0.370, -0.359, -0.717, -0.622, -0.554, -0.708, P＜0.001). Ordered logistics regression analysis showed that β-ALP, 25(OH)D3 and PTH were protective factors for sarcopenia in RA patients with different disease activity (OR=0.488, 0.776, 0.115). The area under the receiver operating characteristic (ROC) curve of combined indexes for predicting sarcopenia in RA patients was 0.984, with sensitivity and specificity of 0.920 and 0.946 respectively. 
Conclusion In patients with mild, moderate and severe rheumatoid arthritis, the more obvious the decrease of T12-L2, β-ALP, 25(OH)D3 and PTH, the higher the risk of sarcopenia. β-ALP, 25(OH)D3 and PTH are protective factors, and their combined detection has high predictive value for sarcopenia in RA patients. 

Objective To analyze the diagnostic value and correlation of 25-hydroxyvitamin D ［25-(OH)D］, D-dimer (DD), and procollagen Type Ⅰ N-terminal propeptide (PINP) in postmenopausal osteoporosis (PMOP) in postmenopausal women. 
Methods A total of 255 postmenopausal women who underwent physical examinations in the Physical Examination Center of Shanghai Health and Medical Center from January 2022 to December 2024 were collected as research subjects and divided into three groups according to the lowest T value of bone mineral density (BMD): normal group (T value≥-1.0), osteopenia group (-2.5＜T value＜-1. 0), and osteoporosis group (T value≤-2.5). The serum 25-(OH)D, DD and PINP concentrations were compared among the three groups. The correlation between serum 25-(OH)D, DD and PINP concentrations and L1-4 BMD, femoral neck BMD and left hip BMD in postmenopausal women was analyzed by Pearson correlation analysis. The diagnostic efficacy of serum 25-(OH)D, DD and PINP in PMOP was analyzed by receiver operating characteristic (ROC) curve. 
Results The age ［(59.98±3.49)years］ and menopause duration ［(7.28±2.39) years］ of the osteoporosis group were significantly higher than those of the normal group ［(52.76±3.87) years, (2.90±2.57) years］ and the osteopenia group ［(55.02±4.18) years, (4.52±2.99) years］. The total BMD of L1-4 ［(0.730±0.064）g/cm2］, femoral neck BMD［(0.680±0.057)g/cm2］, and the total BMD of the left hip［(0.868±0.059)g/cm2］ were significantly lower in the osteoporosis group compared with the normal group (P＜0.05). The osteoporosis group had significantly higher age and menopause duration compared with the osteopenia group, and significantly lower total BMD of L1-4, femoral neck BMD, and total BMD of the left hip compared with the osteopenia group (P＜0.05). The 25-(OH)D level ［(17.70±7.28)μg/L］ in the osteoporosis group was significantly lower than that in the osteopenia group ［(21.15±4.88 )μg/L］ and the normal group ［(25.43±4.15)μg/L］, while DD ［(0.52±0.16)mg/L］ and PINP ［(67.94±15.76)μg/L］ were significantly higher than those in the other two groups (P＜0.05). The 25-(OH)D concentration in the osteoporosis group was significantly lower than that in the osteopenia group, while the DD and PINP concentrations were significantly higher than those in the osteopenia group (P＜0.05). Pearson correlation analysis revealed that serum 25-(OH)D concentrations in postmenopausal women were positively correlated with total BMD of L1-4, femoral neck BMD, and total BMD of the left hip (P＜0.001), while serum DD and PINP concentrations were negatively correlated with total BMD of L1-4, femoral neck BMD, and total BMD of the left hip (P＜0.001). The are under the ROC curve (AUC) values of 25-(OH)D, DD, and PINP alone and in combination for the diagnosis were 0.765, 0.852, 0.712, and 0.968, respectively, and serum 25-(OH)D, DD, and PINP all had certain diagnostic value in diagnosing PMOP. The combined diagnosis had a sensitivity of 96.7% and specificity of 88.2%, and the combined diagnostic value was significantly better than the single diagnosis of each serum indicator (Z=7.036, 12.927, 5.219, 43.446, all P＜0.05). 
Conclusion Serum 25-(OH)D, DD, and PINP levels are closely related to BMD in different body parts, and have certain diagnostic value in the diagnosis of PMOP, and the combined diagnostic value is higher. 

Objective To explore the clinical value of CT-guided spring coil localization in thoracoscopic resection of subsolid nodules. 
Methods A retrospective analysis was conducted on 120 patients with solitary subsolid nodules (early stage lung cancer) in Shijiazhuang People′s Hospital from January 2022 to October 2024, who were divided into the research group (preoperative spring coil localization) and the control group (direct surgery) by using a random number table method. The success rate of localization, surgery-related indexes (duration of operation, intraoperative bleeding, number of staple cartridges used), postoperative recovery (retention time of chest tube, length of postoperative hospitalization) and changes in psychological status assessed by self-rating anxiety scale (SAS) and self-rating depression scale (SDS) were compared between the two groups. 
Results The success rate of localization in the research group was 100%, and only 1 patient experienced a small amount of pneumothorax; 1 patient in the control group required intraoperative CT localization. The research group was significantly superior to the control group in terms of duration of operation ［(94.200±25.170) min vs. (127.950±35.050) min, P＜0.05］, length of postoperative hospitalization ［(5.250±1.251) d vs. (7.000±1.522) d, P＜0.05］, and retention time of chest tube ［(2.900±0.641) d vs. (3.350±0.587) d, P＜0.05］. There was no significant difference between the two groups in terms of intraoperative bleeding, number of staple cartridges used and hospitalization expenses (P＞0.05). Psychological assessment showed that postoperative SAS and SDS scores of patients in the research group were significantly lower than those of the control group (P＜0.01). All surgeries were completed successfully, with no patient undergoing intermediate open chest and no residual spring coils or other serious complications. 
Conclusion CT-guided spring coil localization can improve the efficiency of surgery, shorten the postoperative recovery time, and improve the psychological state of patients, which is a safe and precise preoperative localization method worthy of clinical popularization.