A comparative study of applying TSPOT.TB and TST in the diagnosis of LTBI in TB professionals

doi:10.3969/j.issn.10073205.2016.07.008

Abstract

Abstract: [
Abstract ] Objective ToinvestigatethevalueofT-SPOT.TBinthediagnosisoflatent
tuberculousinfection ( LTBI ) inTBprofessionals.Methods Eight-fivecasesofTBmedicalstaff
asTBprofessionalswereselected.Eight-fivecasesofhealthypeoplewereselectedforcontrol
group , allwithoutpreviousTBhistoryorsymptomsand withnormalchestfilm.Apply T-
SPOT.TBwasdetectedbythespecificinterferon γ ( IFN-γ ) leveloftheperipheralblood.
Tuberculinskintest ( TST ) wasusedalso.TBbacilluswhilecarryingoutparallelTSTtests.
Results T-SPOT.TBresultsshowthatthedifferencebetweenthestudygroupandthecontrol
groupwasstatisticallysignificant.TSTindicatesthatthereisnostatisticdifferencebetweenthe2
groups.Thepositiveratecomparisonofthetwomethodsshowsthatthereisstatisticdifference
betweenthe2groups ( P <0.05 ) .Consistencycheckindicatesthatthereispoorconsistency
betweenthetwotest methods ( Kappa=0.123 ) .Conclusion ①Closelycontacting with TB
infectedpatientsisariskfactorwhichleadstoMTBinfection.Peoplewithclosecontacthavea
higherrateofbecomingLTBIpatientsthanthosewithoutclosecontact.②T-SPOT.TBpositive
resultsarepositivelycorrelatedwiththosewhocloselycontactwithTBinfectedpatients , while TSTpositiveresultsarenotcorrelated , probablyduetoaveryhighBCGvaccinationratein
China.③T-SPOT.TBhasahigherspecificitythanTSTinLTBIdiagnosis.④T-SPOT.TBhasa
lowcorrelationwithTSTandservesasamoreaccuratemethodofLTBIdiagnosis.

Key words: latenttuberculosis , tuberculintest , diagnosis

SONG Tao1, LI Lijuan2, FU Hongyi1. A comparative study of applying TSPOT.TB and TST in the diagnosis of LTBI in TB professionals[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.07.008.

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A comparative study of applying TSPOT.TB and TST in the diagnosis of LTBI in TB professionals

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