Abstract: ［Abstract］ Objective〖HTSS〗〓To explore the application of shearwave elastography(SWE) quantitative analysis to evaluate the pathologic response in breast cancer after adjuvant chemotherapy and its correlation with tumor hemoglobin.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 56 patients with breast cancer(56 lesions) were treated with neoadjuvant chemotherapy(NAC) and surgery after biopsy diagnosis. The maximal modulus of elasticity was measured by SWE before and after NAC chemotherapy, the total hemoglobin concentration(HbT) was measured by USdiffuse optical tomography(USDOT). The pathological evaluation was chosen as gold standard. The efficacy of NAC evaluation by the RECIST1.1 and the maximum elastic modulus was compared, and the correlation between HbT and HbT was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The reduction rate of tumor diameter, HbT value and maximum elastic modulus in significant pathological response patients were significant different with nonsignificant pathological response patients（P＜005）. The sensitivity, specificity, accuracy and Kappa values of NAC evaluation by RECIST1.1 were 86.4%, 91.7%, 87.5% and 0.678, and the sensitivity, specificity, accuracy and Kappa values of NAC evaluation by maximal modulus of elasticity were 88.6%, 75.0%, 85.7% and 0.600, there was no difference in two groups（P＞005）. There was a significant positive correlation between the maximum elastic modulus reduction rate and the HbT reduction rate(r=0.785, P=0.000).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The maximal modulus of elasticity of breast lesions measured by SWE can reflect tumor hemoglobin level objectively, wihch can be convenient, effective and accurate to evaluate NAC effacy with reduction rate of maximum elastic modulus.

Key words: neoplasms； chemoradiotherapy, adjuvant, hemoglobins