Abstract: ［Abstract］ Objective〖HTSS〗〓To observe the level changes of blood glucose related indexes in patients with nondiabetes but with cerebral infarction secondary prevention, when they took different doses of atorvastatin or rosuvastatin to regulate blood lipids.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓One  hundred and fifty patients were randomly divided into 5 groups, 30 patients in each group. They were respectively treated with 10 mg atorvastatin, 20 mg atorvastatin, 40 mg atorvastatin, 10 mg rosuvastatin or 20 mg rosuvastatin by oral  administration once a night. The course of treatment was 24 weeks. The level changes of fasting triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDLC), fasting blood glucose(FBG) and glycosylated hemoglobin(HbA1c) in those patients were observed before and after treatment.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, the level of TG, TC and LDLC of each group were significantly decreased, HbA1c level of 20 mg atorvastatin group was significantly increased and the level of FBG and HbA1c of 40 mg atorvastatin group were significantly increased(P＜005). Pairwise comparison among groups after treatment: the level of TG, TC and LDLC of 10 mg atorvastatin group were significantly higher than those of other four groups, those of 40 mg atorvastatin group were significantly lower than those of 20 mg atorvastatin group and two rosuvastatin groups. Those of 20 mg rosuvastatin group were significantly lower than those of 10 mg rosuvastatin group(P＜005). HbA1c level of 40 mg atorvastatin group were significantly higher than that of other four groups(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The effect of rosuvastatin on FBG and HbA1c is less than that of atorvastatin when the lipidlowering effect of rosuvastatin is the same as that of atorvastatin.

Key words: brain infarction； atorvastatin, rosuvastatin