Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare the effects of  the sodium valproate(VPA) and levetiracetam(LEV) monotherapy on the changes of electroencephalogram(EEG) interphase discharge quantity and the clinical effect in generalized seizures.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The 140 cases of various generalized epilepsy children were selected andrandomly and were divided into control group and observation group, 70 cases in each group. Control group was treated with sodium valproate. The observation group was treated with levetiracetam. The changes of EEG epileptiform discharge, seizure control and safety before and after treatment were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After treatment, the change of EEG in the observation group was better than that in the control group, and the proportion of interictal epileptiform activity(IEA) disappearing or decreasing by more than 50% was higher than that in the control group（P＜005).The clinical efficacy of the observation group was better than that of the control group, and the difference was statistically significant（P＜005), while the total effective rate of the two groups was not statistically significant（P＞005).There was no statistically significant difference in the incidence of adverse reactions between the two groups（P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓LEV is effective in the treatment of all types of children with generalized epileptic seizures. It has significant effect in improving IEA, low incidence of adverse reactions and good safety.

Key words: epilepsy； levetiracetam, sodiumvalproate, electroencephalogram