Abstract: ［Abstract］ Objective〖HTSS〗〓To analyze expression and correlation of androgen receptor(androgen receptor, AR) , estrogen receptors(estrogen receptor, ER) and thyroid stimulating hormone receptor(thyroidstimulating hormone receptor, TSHR) in thyroid papillary carcinoma(papillary thyroid carcinoma, PTC) expression and correlation of organization, The roles of the three factors in PTC and prognosis were also discussed.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The expressions of AR, ER and TSHR in 197 cases of PTC, 50 cases of paracancer normal tissues and 50 cases of thyroid benign tumors were detected by immunohistochemistry.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The positive expression of ER and TSHR in PTC tissues and paraPTC tissues were significantly higher than those in benign thyroid neoplasms, and the positive expression of AR was significantly lower than that in benign thyroid neoplasms（P＜005）. The positive rate of ER, TSHR and AR expression in female was higher than that in male. The positive rate of ER expression in patients aged＜45 years was higher than that in patients aged≥45 years. The positive expression rates of ER and TSHR in patients with capsule infiltration were higher than those without. The positive rates of ER and TSHR expression in patients with tumor diameter 4 cm were higher than those with tumor diameter<4 cm. The positive rates of ER and TSHR expression in patients with lymph node metastasis were higher than those without lymph node metastasis. Tumor staging Ⅲ-Ⅳ ER and TSHR expression positive rate was higher than the tumor staging Ⅰ-Ⅱ, the differences were statistically significant(P＜005). There was a positive correlation between ER and TSHR protein expression in PTC tissues(rs=0575, P＜005), and a negative correlation between ER and AR, AR and TSHR protein expression in PTC tissues(rs=-0.160, P＜005, rs=-0.186, P＜005), but the correlation was weak.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Combined detection of ER and TSHR is expected to be an important indicator for the diagnosis of PTC invasion and metastasis. AR may be a protective factor, and high expression of AR in PTC indicates a better prognosis.

Key words: thyroid , neoplasms； receptors, androgen； receptors, estrogen