Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the relationship between the inflammatory pathway of Tolllike receptor 4(TLR4)/nuclear factor kappa B(NFκB) and the pathogeny and severity of hand, foot and mouth disease(HFMD).
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 78 children with HFMD were selected and divided into EV71 infected HFMD group(34 cases) and nonEV71 infected HFMD group(44 cases). According to the existence of neurological complications, they were divided into 47 cases of HFMD common type group and 31 cases of HFMD severe type group. Thirtyfive healthy children were selected for physical examination at the same time. The levels of TLR4 and NFκB in peripheral blood of all subjects were detected by enzymelinked immunosorbent assay. The relationship between TLR4 and NFκB in peripheral blood and enterovirus typing and severity of HFMD was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The levels of TLR4 and NFκB in peripheral blood of EV71 group and nonEV71 group were higher than those of control group, the levels of TLR4 and NFκB in peripheral blood of EV71 group were higher than those of nonEV71 group(P＜005), and the levels of TLR4 and NFκB in peripheral blood of severe group were higher than those of normal group(P＜005). The pathogen and severity of HFMD were positively correlated with the levels of TLR4 and NFκB in peripheral blood(P＜005). After controlling the severity of the variables, the levels of TLR4 and NFκB in peripheral blood of children with hand, foot and mouth disease in nonEV71 and EV71 groups were positively correlated(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓EV71 infection is associated with the development and severity of TLR4/NFκB inflammatory signaling pathway.

Key words: hand, foot and mouth disease, Tolllike receptor 4, nuclear factorkappa B