Abstract: ［Abstract］ ObjectiveTo explore the changes and clinical significances of neural electrophysiological parameters in patients with diabetes. Methods Changes of neural electrophysiological parameters were analyzed in 121 diabetic patients .  According to the course of disease(by 10 years), the electrophysiological indexes were analyzed. ResultsThere was difference in the electrophysiological indexes of 121 patients with diabetes mellitus. In more than 10 years group, thd decreased abnormal rates of conduction velocity in the median nerve, peroneal nerve and tibial nerve motor nerve were increased(P＜0.05). The abnormal rates of latency in median nerve and ulnar nerve were higher than that in <10 years group(P＜0.05). The decreased abnormal rate of amplitude in peripheral motor nerve was also increased, but the difference was not statistically significant in two groups(P＞0.05). In more than 10 years group, the conduction velocity decreased abnormal rates in sensory nerve median nerve, ulnar nerve and radial nerve were increased（P＜0.05）. The decreased and the abnormal rate of amplitude in median sensory nerve was increased(P＜0.05). ConclusionThe regular nerve electrophysiological examination in patients with diabetes will be helpful for early detection, early diagnosis and early treatment of diabetic peripheral neuropathy.

Key words: diabetes, diabetic peripheral neuropathy, nerve electrophysiology