Contentandclinicalsignificanceofinterleukin-6andtumornecrosis#br#
factor-αofsalivainpatientswithrecurrentaphthousulceration

doi:10.3969/j.issn.10073205.2016.11.012

Journal of Hebei Medical University

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Contentandclinicalsignificanceofinterleukin-6andtumornecrosis#br# factor-αofsalivainpatientswithrecurrentaphthousulceration

1.Department of Stomatology, the Fourth Hospital of Hebei Medical University, Shijiazhuang
050011, China； 2.Department of Stomatology, the First Hospital of Hebei Medical University,
Shijiazhuang 050031, China; 3.Department of Stomatology, the First Hospital of
Hebei Medical Unniversity, Shijiazhuang 050031, China

Online:2016-11-25 Published:2016-12-14

Abstract

Abstract: [
Abstract ] Objective Toevaluatesalivaryinterleukin ( IL ) -6andtumornecrosisfactor
( TNF )
-αofpatientswithrecurrentaphthousulceration ( RAU ) .Methods Atotalof30patients
withRAU wereselectedastheresearchsubjects , including18casesofulcerand12casesof
intermittentperiod.Thrityhealthyvolunteerswereusedasnormalcontrol.TNF-αandIL-6
levelsweredeterminedbyusingenzyme-linkedimmunosorbentassay.Results Thecontent
differenceofTNF-αinthe3groupswasstatisticallysignificant , theulcerphaseandtheinterval
groupwerehigherthanthoseinthecontrolgroup , whiletheintervalgroupwashigherthanthat
oftheulcergroup , thedifferencewasstatisticallysignificant (
P <0.05 ) .IntheIL-6content ,
therewasnosignificantdifferencebetweenthe3groups ( P >0.05 ) .Therewasnocorrelation
betweenthelevelsofTNF-αandIL-6insalivaofRAUpatients ( r =-0. 090 , P =0. 638 ) .Conclusion
TNF-αcontentincreasedinsalivamaybeoneofthemainriskfactorsofRAUetiology.

Key words: oralulcer , saliva , interleukin-6 , tumornecrosisfactor-alpha

ZHANG Suxin1, LI Dan2, CHEN Zhong1, ZHANG Yuwen1*, ZHANG Jinhong2, XU Yanzhi1*. Contentandclinicalsignificanceofinterleukin-6andtumornecrosis#br# factor-αofsalivainpatientswithrecurrentaphthousulceration[J]. Journal of Hebei Medical University, doi: 10.3969/j.issn.10073205.2016.11.012.

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Contentandclinicalsignificanceofinterleukin-6andtumornecrosis#br# factor-αofsalivainpatientswithrecurrentaphthousulceration

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