Abstract: [ Abstract ] Objective Toinvestigatetheeffectofdifferentdosesofω-3polyunsaturatedfatty
acidoninflammatoryfactors , nutritionalstatusandpostoperativecomplicationsinpatientswith
esophagealcarcinoma.Methods Ninety-twopatients wtihesophaguscancer wererandomly
dividedintoacontrolgroup ( 32cases ), experimentalgroup1 ( 30cases ) andtheexperimental
group2 ( 30cases ) .Allpatientsweregiven6daysofparenteralnutritionsupporttreatment
, and
thenweregivenliquiddietafterrecoveryofgastrointestinalfunction.Controlgroupwasgiven
saline100 mL / d , the experimentalgroup 1 weretreated with saline 50 mL / d and ω-3
polyunsaturatedfatty acid 50 mL / d , the experimental group 2 were treated with ω-3
polyunsaturatedfattyacid100 mL / d , allthetreatmentcourse wasone week.Procalicitonin
(
PCT ), C-reactiveprotein ( CRP ) andinterleukin-6 ( IL-6 ), albumin ( Alb ), lymphocyte ( LYM ),
prealbumin ( PA ) andtransferrin ( TFN ) ofpatientswerecollectedandcomparedonpreoperative day1 , postoperativeday1 , andpostoperativeday7.Thedrugreactionsandtheoccurrenceof
postoperativecomplicationswererecorded.Results Onpostoperativeday7 , thePCT , CPRand
IL-6ofexperimentalgroup1andexperimentalgroup2werelowerthanthatofconrolgroup
( P <0.05 ), the PCT , CPR andIL-6 ofexperimentalgroup2 werelowerthan that of
experimentalgroup1 ( P <0.05 ), theLYM ofexperimentalgroup1andexperimentalgroup2
werehigherthanthatofconrolgroup ( P <0.05 ), theLYMofexperimentalgroup2werehigher
thanthatofexperimentalgroup1 ( P <0.05 ) .Therewere3casesofwoundinfection , 2casesof
pulmonaryinfection , 1casesofanastomoticleakageincontrolgroup , 3casesofwoundinfection
inexperimentalgroup1 , 3casesofpulmonaryinfectionand1casesofincisioninfectionin
experimentalgroup2.Theincidenceofcomplicationswas3. 33% ( 1 / 30 ) inexperimentalgroup2 ,
whichwaslowerthanthatincontrolgroup21. 88% ( 7 / 32 ) andtheexperimentalgroup2 ( P <
0.05 ) .Theincidenceofcomplicationswerenotstatisticallysignificant ( P >0.05 ) .Conclusion ω-
3polyunsaturatedfattyacidscanreducetheinflammatoryreactioninpatientswithesophageal
cancer , andimprovethenutritionalstatusofpatientsaftersurgery.Theapplicationoflargedose
ismoreobvious , andcanreducetheincidenceofpostoperativecomplications.

Key words: esophagus cancer； &omega, 3 polyunsaturated fatty acids； postoperative complications