Abstract: Objective To explore the therapeutic effect of traditional Chinese medicine therapy for patients with systemic lupus erythematosus. Methods in our hospital in March 2014 to 2015 August received the systemic lupus erythematosus (SLE) 66 cases of patients as the research object, according to the number of parity method is divided into two groups, with 33 cases in each group, two groups of patients were given blood pressure control, gastric mucosal protective agent and calcium supplement conventional treatment, control group was treated with sulfuric acid hydroxychloroquine joint acetate throwing prednisone treatment, experimental group used traditional Chinese medicine treatment, to observe the effect of the two groups of patients and clinical symptom score changes and adverse reaction incidence. Results in the experimental group, the adverse reaction incidence was 6.06%, was significantly lower than that of the control group of 24.24%, the difference is statistically significant (P < 0.05); two groups of patients before treatment, TCM syndrome integral no significant difference (P > 0.05), among the three groups before and after treatment, significant difference (P < 0.05); after treatment, TCM syndrome score compared experimental group was significantly lower than that of the control group (P < 0.05); the clinical curative effect of experimental group was 93.94%, obviously superior to 84.85% in the control group, the difference is statistically significant (P < 0.05). Conclusion the application of traditional Chinese medicine therapy in the treatment of systemic lupus erythematosus, not only has significant clinical effect, but also can improve the score of TCM syndrome, the adverse reaction is small, and the safety is high.