Abstract: ［Abstract］ Objective〖HTSS〗〓To discuss the correlation of apolipoprotein (APO) C1 expression and neointimal formation.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The intimal hyperplasia model of the mice was prepared by the common carotid artery ligation. HE staining was used to test the neointima. Western blot was used to detect the protein expression of APOC1 and SM22α, Immunofluorescence was used to detect the protein expression and distribution of APOC1.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓With the extension of time of ligation,the intimal hyperplasia was observed in the carotid arteries of mice after the ligation. At different time points of the common carotid artery ligation. the expression of SM22α was decreased in neointimal region. The expression of APOC1 was gradually increased, which was contrary to that of SM22. Immunofluorescence staining also showed that the fluorescence intensity of APOC1 was enhanced in the area of thickened intima, and it is positively correlated with the thickness of intima.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The expression of APOC1 may be involved in vascular smooth muscle cell switching and vascular remodeling.

Key words: tunica intima, apolipoproteins C, muscle, smooth