Abstract: ［Abstract］ Objective〖HTSS〗〓To study the therapeutic effects of Rhodosin on cognitive function in Alzheimer disease(AD) rats.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓The AD rat models and Rhodosin intervention models were established. Learning and memory abilities of rats were tested by the Morris water maze. The protein expressions of AKT, pAKT, GSK3β, PGSK3β, bcl2 and bax were examined via Western blotting. And the ultrastructure of hippocampus neurons was determined by transmission electron microscopy.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After modeling, the latent period of the model group and Rhodosin group was prolonged than that in the control group. After treatment, the latent period of the model group and Rhodosin group was prolonged than that in the control group. The Rhodosin group was shorter than the model group(P＜005). After modeling, the stay time of the target quadrant in model group and Rhodosin group was significantly shorter than the control group, the difference was statistically significant(P＜005).  After treatment, the stay time of the target quadrant in model group and Rhodosin group was also shorter than the control group, but the Rhodosin group was longer than the model group(P＜005). The protein expressions of pGSK3β in the model group and Rhodosin group was lower than that in the control group, Rhodosin group higher than model group. The protein expressions of pAKT in Rhodosin group was higher than control group and model group, model group lower than control group(P＜005). The protein expressions of bcl2 in model group lower than control group, Rhodosin group was higher than control group and model group(P＜005). The bax protein expressions in model group was high than control group and Rhodosin group(P＜005). 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓 Rhodosin could improve cognitive function in AD rats. Its mechanisms may be through upregulating antiapoptotic protein bcl2 and downregulating proapoptotic protein bax via the PI3K/AKT/GSK3β pathway.

Key words: Alzheimer disease, RHODIOLA SACRA； apoptosis