Abstract: ［Abstract］  ObjectiveTo investigate the association of PNPLA3 gene polymorphisms (rs738408, rs738409, rs2294918, rs2294919 and rs2281135) with chronic infection of hepatitis B virus vaccine(HBV). MethodsCase control study was used. For chronic HBV infection in line with the conditions included (case group) 1 792 cases, chronic HBV infection (control group) 618 cases, the association between multiple SNP loci of PNPLA3 gene and susceptibility to HBV infection was analyzed by statistical methods such as   test and multiple Logistic regression analysis. ResultsThe subjects with the PNPLA3 rs738408 TC/TT genotype might have lower risk of HBV infection(OR=0.059, 95% CI=0.028-0.125, P<0.001 for TC; OR=0.020, 95%CI=0.007-0.053, P<0.001 for TT), the subjects with rs738409 GG genotype had a 27.550(95% CI=10.024-75.718, P<0.001) times higher odds of HBV infection. rs2294918 AA genotype might reduce the risk of HBV infection(OR=0.354, 95% CI=0.210-0.599, P<0.001). rs2294919 TC genotype had a 0.598 (95% CI=0.429-0.833， P=0.002) times lower odds of HBV infection. The results mentioned above were adjusted by sex, age, smoke and drink values. ConclusionThere was significant relationship between PNPLA3 gene polymorphisms(rs738408 TC or TT, rs738409 GG, rs2294918 AA and rs2294919 TC) and HBV infection.

Key words: hepatitis B virus, genes； disease susceptibility