Abstract: ［Abstract］〓Objective〖HTSS〗〓To investigate the effects of ibandronate on intervertebral fusion the lumbar spondylolisthesis patients underwent lumbar posterior decompression and interbody fusion and internal fixation.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixtythree cases of lumbar spondylolisthesis patients were underwent lumbar posterior interbody fusion and internal fixation. The patients were divided into experimental group and control group according to different postoperative drug use. The experimental group of 33 patients used 3mg ibandronate for 120 minutes by slow intravenous a week after surgery, every 3 months for 24 months. The control group of 30 patients did not use the application of ibandronate drugs. The two groups were evaluated on the low back pain Oswestry Dability Index(ODI) score, lumbago leg pain symptoms Visual Analogue Scale(VAS) score, bone density, Xray and CT examinations  before and at the last followup and the clinical symptom score, intervertebral height, fusion rate and bone mineral density were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓At the end of the followup, pain ODI score and VAS score of two groups were significantly lower than those before operation, the experimental group was lower than the control group according to the ODI score and VAS score of the lumbago(P＜005). The height of the intervertebral space of the 2 groups was smaller than that of the postoperative, the height of the intervertebral space of the experimental group was higher than that of the control group, loss of intervertebral height was less in experimental group, and the interbody fusion the rate of experimental group was higher than the control group(P＜0.05). The bone mineral density of the lumbar spine and the bone mineral density of the left femur were higher in the experimental group than in the control group, the bone mineral density of the lumbar spine and the bone mineral density of the left femur were higher in the experimental group than those in the control group(P＜0.05).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓Application of ibandronate can promote interbody fusion, improve the symptoms of low back pain after the posterior lumbar decompression and reduction and interbody fusion.

Key words: spondylolysis, spinal fusion, ibandronate