Journal of Hebei Medical University

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Relationship among nonalcoholic fatty liver disease, hyperuricemia and dyslipidaemia in health checkup polulation

  

  1. Health Management Center, Bethune International Peace Hospital of PLA, Shijiazhuang 050082, China
  • Online:2018-08-25 Published:2018-07-25

Abstract: 〗[Abstract] Objective〖HTSS〗〓To investigate the relationship among nonalcoholic fatty liver disease(NAFLD),  hyperuricemioa(HUA), and dyslipidemias in checkup population.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 8 330 healthy people who underwent health checkup were recruited in this study, who had met inclusion and exclusion standard. The demographic characteristics and detection condition of NAFLD were analyzed, indicators between NAFLD group and nonNAFLD group, indicators and detection rate of NAFLD between HUA group and nonHUA group were observed and compared.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The median age of the 8 330 healthy people was 43 years old and the interquartile distance was 18 years. The total detection rate of NAFLD was 33.6%. Compared with those in nonNAFLD group, in NAFLD group, body mass index(BMI), waisttostature ratio(WSR), blood glucose(GLU), serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDLC) and uric acid(UA) level was significantly increased, while values of high density lipoprotein cholesterol(HDLC) level were decreased(P<001). Whether the gender, in HUA group, BMI, WSR, GLU, TC, TG, LDLC and UA levels were significantly increased, and HDLC level was significantly decreased, and detection rates of NAFLD were significantly higher than NonHUA group(P<001). Logistic regression analysis and area under the ROC curve showed that HUA level was an independent risk factor for NAFLD. Spearman′s correlation analyses showed a positive correlation between HUA and BMI, WSR, GLU, TC, TG, LDLC and negative correlation between HUA and HDLC. 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓NAFLD is closely related to dyslipidemias. HUA is an independent risk factor for NAFLD.

Key words: fatty liver, alcoholic, hgyperuricemia, Health checkup