Abstract: ［Abstract］ Objective〖HTSS〗〓To study the effect of bilevel positive pressure ventilation on blood pressure in patients with refractory hypertension complicated with obstructive sleep apnea syndrome.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓A total of 114 patients with resistant hypertension combined with obstructive sleep apnea hypopnea syndrome were selected. The levels of renin, angiotensin Ⅱ, aldosterone, 24hour ambulatory blood pressure, multiple sleep monitoring, apnea hypopnea index, and minimum oxygen saturation were measured before the trial. Then each subject was given a bilevel positive pressure ventilation treatment for at least 6 hours every evening. Patients were followed up for 6 months. After the trial the levels of renin, angiotensin Ⅱ, aldosterone, 24 hour ambulatory blood pressure, multiple sleep monitoring, apnea hypopnea index, and minimum oxygen saturation were measured in the patients again . After followup for 6 months, the above indicators were compared with those before the trial.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓After 6 months bilevel positive pressure ventilation the apnea hypopnea index and oxygen saturation<90% were lower than before, and minimum oxygen saturation and mean oxygen saturation were uppered. The difference was statistically significant(P＜005). Systolic blood pressure and diastolic blood pressure in 24 h, systolic blood pressure and diastolic blood pressure in daytime, systolic blood pressure and diastolic blood pressure at night were compared with those before treatment, all were lowered, and the difference was statistically significant(P＜005). The blood pressure variability was reduced after the treatment, compared to that before the trial, the difference was statistically significant(P＜005). The levels of renin, angiotensin Ⅱ, aldosterone were also decreased compared with those before treatment. And the difference was statistically significant(P＜005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓In patients with resistant hypertension combined with obstructive sleep apnea hypopnea syndrome, a bilevel positive pressure ventilation treatment based on drug therapy for 6 months can effectively control the patients' blood pressure.

Key words: hypertension, sleep apnea, obstructive, polysomnography