Abstract: ［Abstract］〓Objective〖HTSS〗〓To compare the effect of prucalopride and itopride combined with polyethylene glycol electrolyte in bowel preparation before colonoscopy.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Totally 160 chronic constipation patients scheduled for colonoscopy were randomly divided into prucalopride and itopride groups, 80 cases in each group. Patients in prucalopride group started taking prucalopride 2 mg per day three days before colonoscopy, and taking the polyethylene glycol electrolyte on the day of colonoscopy；patients in itopride group started taking itopride 50 mg 3 times per day three days before colonoscopy, and taking the polyethylene glycol electrolyte on the day of colonoscopy. The bowel preparation quality, polyp detection rate, time of reaching the ileocecal junction and adverse reactions were compared between the two groups.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓The Boston Bowel Preparation Scale score of the bowel preparation quality and the polyp detection rate of the prucaropride group were higher than that of the itopride group, and the time of reaching the ileocecal group was shorter than that of the itopride group, there was a statistical differences in the two groups(P＜005). There was no significant difference in the incidence rate of adverse reaction between the two groups(P＞005).
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The effect of prucalopride combined with polyethylene glycol electrolyte for colonscopy preparation is better than itopride combined with polyethylene glycol electrolyte.

Key words: constipation, prucalopride, itopride, colonoscopy