Journal of Hebei Medical University

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The preparation and clinical application of Dragon′s blood gel#br#

  

  1. 1.Department of Pharmacy, the First Central Hospital of Baoding, Hebei Province,
    Baoding 071000, China; 2.College of Pharmacy, Kunming Medical University,
    Yunnan Province, Kunming 650500, China
  • Online:2019-02-25 Published:2019-01-16

Abstract: 〗[Abstract] Objective〖HTSS〗〓To prepare the Dragon′s blood gels and to investigate its clinical effect of the gels.
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Orthogonal test was used. Polyvinyl alcohol, polyvinylpyrrolidone, drug quality and glycerol content were taken as the investigation factors. The appearance uniformity, flexibility, heat resistance, cold resistance and centrifugal test of the coating agent were taken as the indexes to select the best formulation of the coating agent. In the clinical experiment, 60 bedsore patients were randomly divided into 2 groups, the control group(pharmaceutical dressing) and observation group(Dragon′s blood gels). The wound healing, cure rate and discharge time of 2 groups of patients with bedsore after medication were observed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Orthogonal test results showed that the formulation of A1B3C3D3 film coating agent had the highest matrix score. Compared with other prescriptions, this prescription has good skin affinity, fast film formation and easy to peel off. The clinical efficacy and cure rate of the observation group were higher than those of the control group, but the difference was not statistically significant(P>005), The discharge rate of the observation group was significantly higher than the control group, the discharge time and drug effective time were shorter than the control group(P<005), which showed significant difference.
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓The preparation technology of Dragon′s blood gels is simple and the gel has good appearance and stability. Moreover, the Dragon′s blood gels have a good effect on bedsore patients.

Key words: Dragon′s blood, orthogonal test, cure bedsore