Journal of Hebei Medical University

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Quantitative application of high frequency ultrasound in monitoring the curative effect of rheumatoid arthritis#br#

  

  1. Department of Rheumatism and Immunology, the Central People′s Hospital of Huizhou, Guangdong Province, Huizhou 516001, China
  • Online:2019-07-25 Published:2019-07-16

Abstract: [Abstract]〓Objective〖HTSS〗〓To investigate the quantitative application of high frequency ultrasound in monitoring the curative effect of rheumatoid arthritis. 
〖HTH〗〖WTHZ〗Methods〖HTSS〗〓Sixty patients with RA were examined by highfrequency ultrasound before treatment, during remission and half a year after remission. Synovial thickness, gray scale(GS) and power Doppler(PD) scores of seven specific joints were observed. Erythrocyte sedimentation rate, Creactive protein and rheumatoid factor levels were measured. The correlation between synovial changes and inflammatory indexes was analyzed.
〖HTH〗〖WTHZ〗Results〖HTSS〗〓Compared with 840 joint ultrasound images of 60 cases of RA patients, synovial membrane thickness and GS score, blood flow PD score, erythrocyte sedimentation rate, Creactive protein and rheumatoid factor levels of 7 joints in remission period after treatment and half a year after remission were significantly lower than or lower than those before treatment. Six months after remission, synovial membrane thickness and GS score, PD score, erythrocyte sedimentation rate, Creactive protein and rheumatoid factor of 7 joints were significantly lower than those before treatment. The levels were significantly lower than or below the remission stage(P<005). The synovial membrane thickness and synovial blood flow were positively correlated with erythrocyte sedimentation rate, Creactive protein and rheumatoid factor(P<005). 
〖HTH〗〖WTHZ〗Conclusion〖HTSS〗〓High frequency ultrasound shows definite significance in the monitoring of rheumatoid arthritis. Simplified GS and PD quantitative scores of 7 joints are positively correlated with inflammation index and rheumatoid factor titer. It has important guiding significance for formulating and adjusting the therapeutic scheme of rheumatoid therapy.

Key words: arthritis, rheumatoid; high frequency ultrasound, efficacy monitoring