Abstract: ［Abstract］ Objective To study the effect of polypolycarnitol combined with Atenolol in treatment of infantile hemangioma in parotid region and its effect on cyclooxygenase 2(COX-2), connective tissue growth factor(CTGF), vascular endothelial growth factor（VEGF）.
Methods Seventy-six patients with hemangioma of parotid gland were randomly divided into control group(38 cases) and observation group(38 cases). In the control group, the children were treated with atenolol, and the observation group was given a local injection of 1% polykarl in the tumor. The clinical efficacy and adverse reactions were compared between two groups.The expression of COX-2, CTGF and VEGF and immune function were compared between two groups of children before and after treatment.
Results The two groups took atenolol for an average of 6 months, and the observation group received 1% polycarnitol for 3 courses on average.The treatment was completed in 76 children, followed up for 12 months without loss of follow-up. The total effective rate of observation group was significantly higher than that of control group(P＜0.05). After treatment, the positive rate of COX-2,CTGF and the level of VEGF in observation group were significantly lower than those in control group. The levels of IgA,IgG and IgM in observation group were significantly higher than those in control group(P＜0.05). During the treatment period, compared with the control group, the adverse reactions in observation group were significantly lower(P＜0.05).
Conclusion Atenolol combined with polycarnitol is effective and safe in the treatment of infantile hemangioma in parotid region. It can inhibit the expression of COX-2, CTGF and VEGF.

Key words: hemangioma, parotid region, atenolol, cyclooxygenase 2