Abstract: ［Abstract］ ObjectiveTo investigate the effects of hypertensive disorder complicating hypertension(HDCP) on neonatal coagulation, neuron specific enolase(NSE) and procalcitonin(PCT) levels.
〖WTHZ〗MethodsA total of 592 neonates born from HDCP patients admitted to our intensive care unit(ICU) were enrolled in the study. The newborns were divided into three groups according to the serious condition of the maternal condition: group A(112 cases with severe pre-eclampsia), group B(197 cases with mild pre-eclampsia), group C(HDCP, 283 cases), 500 cases of neonates born from women who did not have HCDP at the same time were selected as the control group. The coagulation function indexes［prothrombin time(PT）, activated partial thromboplastin time（APTT）, fibrinogen（FIB）, D dimer（D-D）, platelet count（PLT）, fibrinogen degradation product（FDP)］, NSE and PCT levels of each group were measured at 2 h after birth, and comparison between groups was performed. Spearman correlation method was used to analyze the correlation between each index and the severity of HDCP.
〖WTHZ〗Results The differences of the indexes of A, B, C and the control group were statistically significant(P＜0.01). Correlation analysis showed that the levels of PT, APTT, D-D, FDP, PCT and NSE were positively correlated with the severity of HDCP, while the levels of FIB and PLT were negatively correlated with the severity of HDCP(P＜0.05 or P＜0.01).
〖WTHZ〗ConclusionPregnancy-induced hypertension can easily lead to neonatal coagulopathy, which makes neonatal blood in a state of hypocoagulability and secondary fibrinolysis, and increases the risk of neonatal brain injury and infection. The more severe the maternal condition, the more likely the neonatal will cause coagulopathy and brain damage.

Key words: hypertension, pregnancy-induced, calcitonin, phosphopyruvate hydratase