Abstract: ［Abstract］Objective〖HTSS〗To detect mean platelet volume(MPV), platelet distribution width(PDW) and serum total bilirubin(TBIL) in peripheral blood of patients with gestational diabetes mellitus(GDM), and explore its clinical significance.
 〖WTHZ〗Methods〖HTSS〗A total of 154 GDM patients were selected as the study object. According to the estimated glomerular filtration rate(EGFR), 154 GDM patients were divided into 50 cases of normal renal function group, 54 cases of early renal function damage group, 50 cases of renal function damage group, and 50 cases of healthy pregnant women in the same period of pregnancy as the control group. The levels of MPV, PDW and TBIL were detected and analyzed.
 〖WTHZ〗Results〖HTSS〗The MPV, PDW, TBIL and Cystatin C(CysC) values of normal renal function group, early renal function damage group and renal function damage group were higher than those of the control group, the TBIL values of normal renal function group, early renal function damage group and renal function damage group were lower than those of the control group, the crea tinine(CREA) values of early renal function damage group and renal function damage group were higher than those of the control group, and the urea values of renal function damage group were higher than those of the control group, with statistical significance(P＜0.05) The MPV, PDW and CysC values of the early damaged group and the damaged group were higher than those of the normal group, the TBIL values of the early damaged group and the damaged group were lower than those of the normal group, and the urea and crea values of the damaged group were higher than those of the normal group(P＜0.05). The MPV, PDW, CysC, urea and crea values in the renal function damaged group were higher than those in the early renal function damaged group, and the TBIL values in the renal function damaged group were lower than those in the early renal function damaged group(P＜0.05). MPV and PDW were positively correlated with CysC concentration(r=0.478, 0.393, both P＜0.05). There was a negative correlation between TBIL and CysC(r=-0.393, P＜0.05). MPV, PDW and CysC were the risk factors of renal function damage in GDM, TBIL was the protective factor. The sensitivity and specificity of MPV, PDW, TBIL and CysC in the early diagnosis of no obvious renal function injury were higher, among which CysC was the highest and the best.
 〖WTHZ〗Conclusion〖HTSS〗MPV, PDW and TBIL can be used as sensitive and reliable clinical indicators for the diagnosis of early renal function damage of GDM patients.

Key words: diabetes mellitus, mean platelet volume, platelet distribution width, total bilirubin