Abstract: ［Abstract］ Objective〖HTSS〗To analyze the relationship between thyroid stimulating hormone(TSH), homocysteine(Hcy) and intima-media thickness(IMT) in patients with type 2 diabetes mellitus.
〖WTHZ〗Methods〖HTSS〗A retrospective study was conducted to enroll patients with normal thyroid function and normal IMT(40 cases). The normal IMT group was included in the observation group. Patients(40 cases) with normal thyroid function IMT thickening were included in the observation group, 45 healthy people were included in the control group. The age, course of diabetes, Hcy, TSH, serum total cholesterol(TC), body mass index(BMI), triglyceride(TG), high density lipoprotein cholesterol(HDL-C) were compared between IMT normal group, IMT thickening group and control group low density lipoprotein cholesterol(LDL-C), fasting blood glucose(FPG), glycosylated hemoglobin(HbA1c), IMT and serum creatine(SCR) levels.
〖WTHZ〗Results〖HTSS〗Compared with the control group, the age, FPG, Hcy, TSH, HbA1c levels in the normal IMT group were significantly increased, and HDL-C was decreased. The above differences were statistically significant(P＜0.05). Compared with the control group, age, BMI, FPG, TG, Hcy, TSH, HbA1c, IMT were significantly increased in the IMT thickening group, and HDL-C was significantly decreased, the difference was statistically significant(P＜0.05). Compared with the normal IMT group, the IMT thickening group was older, and the BMI, MT, TG, and FPG were all increased, and the difference was statistically significant(P＜0.05). IMT was positively correlated with TSH(r=0.012, P=0.048), positively correlated with Hcy(r=0.003, P=0.002), and positively correlated with BMI(r=0.069, P=0.013).
〖WTHZ〗Conclusion〖HTSS〗The carotid intima-media thickness of patients with type 2 diabetes is affected by many factors, such as BMI, TG, FPG, TSH, Hcy, etc. Among them, Hcy, BMI, TSH and IMT thickening are risk factors for predicting atherosclerosis .

Key words: diabetes, type 2； thyroid stimulating hormone； intima-media thickness； thyrotropin, Carotid Intima-Media Thickness, atherosclerosis