Abstract: Objective To explore the relationship between Down's screening serum markers and gestational diabetes mellitus(GDM).
Methods The clinical data of 202 pregnant women(GDM group) and 337 normal pregnant women (control group) with GDM were analyzed retrospectively. The serum levels of human chorionic gonadotropin(β-HCG), pregnancy-associated plasma protein-A(PAPP-A) and alpha-fetal protein(AFP), β-HCG, unconjugated estriol(uE3) in 2 groups were compared. Logistic multivariate analysis was used to determine the influencing factors of GDM, and the working characteristic curve of subjects was used to analyze the predictive value of serum markers to GDM.
Results The body mass index (BMI) in GDM group was higher than that in the control group, and the multiple of median(MoM) of PAPP-A in GDM group was lower than that in the control group(P＜0.01). Logistic regression analysis showed that BMI≥ 24, PAPP-A MoM<0.8 and β-HCG MoM≥1.5 in the first trimester were the influencing factors of GDM. ROC curve analysis showed that BMI and PAPP-A MoM predicted the areas of ROC in GDM were 0.664 and 0.687 respectively.
Conclusion BMI in early pregnancy and the level of PAPP-A in serum are the influencing factors of GDM.

Key words: diabetes, gestational, pregnancy-associated plasma protein-A, human chorionic gonadotropin