Abstract: Objective〖HTSS〗To explore the effect of high flow oxygen inhalation through nose on the efficacy and short-term prognosis of patients with acute exacerbation of chronic obstructive pulmonary disease(AECOPD, AECOPD) and type II respiratory failure.
〖WTHZ〗Methods〖HTSS〗Sixty-six patients with AECOPD combined with type Ⅱ respiratory failure were selected as the research object. The simple random number table method was divided into a research group and a control group, 33 cases in each group.Patients in both groups received basic comprehensive treatment, patients in the control group received noninvasive positive pressure ventilation, and patients in the study group received nasal high-flow oxygen therapy.The changes of blood gas indexes and vital signs indexes before and after treatment were compared between two groups of patients, as well as clinical efficacy and short-term prognosis.
〖WTHZ〗Results〖HTSS〗After treatment, the pH, arterial partial pressure of oxygen(PaO2 supplement), and oxygenation index(PaO2/FiO2) of the two groups of patients were higher than before treatment, and the patients in the study group were higher than those in the control group. The respiratory rate(RR) and heart rate(HR) of the two groups of patients were lower than before treatment, and the patients in the study group were lower than those in the control group, the difference was statistically significant(P＜0.05). The total effective rate of clinical efficacy in the study group was 96.97%, which was much better than 81.82% in the control group, and the difference was statistically significant(P＜0.05). There was no significant difference in 28 day tracheal intubation rate and 90 day mortality rate between two groups(P＞0.05), while the improvement rate of the study group was 84.85%, which was higher than that of the control group, 63.64%. Statistical significance(P＜0.05).
〖WTHZ〗Conclusion〖HTSS〗The effect of transnasal high flow oxygen inhalation on AECOPD patients with type Ⅱ respiratory failure is significant, and the short-term prognosis is satisfactory, which is worthy of clinical application.

Key words: pulmonary disease, chronic obstructive, respiratory insufficiency, Transnasal hyperflow oxygen inhalation