Abstract: Objective〖HTSS〗To observe the efficacy of laparoscopic double-lobe resection combined with uterine artery occlusion in the treatment of adenomyosis and their impact on the levels of syndecan-1(SDC-1), heparanase(HPA) and vascular endothelial growth factor(VEGF).
〖WTHZ〗Methods〖HTSS〗A total of 60 patients with adenomyosis in our hospital were selected and divided into observation group and control group according to different surgical methods. The control group was treated with double valve resection, while the observation group was conducted uterine artery occlusion on the basis of the control group. Clinical curative effect, total effective rate, operation time, intraoperative blood loss, postoperative intraperitoneal drainage volume, postoperative intraperitoneal drainage time, changes in Hb, hospital stays, total pregnancy rate at 10 months after surgery, changes in menstrual period, uterine volume, CA125,SDC-1, HPA and VEGF levels were observed before and after surgery in two groups.
〖WTHZ〗Results〖HTSS〗The clinical curative effect of the observation group was better than that of the control group, and the total effective rate was higher than that of the control group. There was a statistically significant difference (P＜0.01 or P＜0.05). In the observation group, the operation time, intraoperative bleeding volume, postoperative abdominal drainage volume, postoperative abdominal drainage time, changes of Hb before and after operation and hospitalization time were significantly shorter or less than those in the control group(P＜0.01), while the cumulative pregnancy in the 10 months after operation was higher than that in the control group(P＜0.05). After treatment, the menstrual period, uterine volume and CA125 level of the two groups were significantly shortened, less or decreased compared with those before treatment, with statistical significance(P＜0.01); The menstrual period, uterine volume and CA125 level of the observation group were significantly shortened, less or decreased compared with the control group, with statistical significance(P＜0.01). After treatment, the levels of SDC-1, HPA and VEGF in the two groups were significantly lower than those before treatment(P＜0.05); The levels of SDC-1, HPA and VEGF in the observation group were significantly lower than those in the control group(P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗Laparoscopic double-lobe resection combined with uterine artery occlusion is effective in the treatment of adenomyosis, which can significantly relieve dysmenorrhea and 〖JP2〗reduce the volume of uterus. The mechanism may be related to the reduction of the levels of SDC-1,〖JP〗 HPA and VEGF.

Key words: liomyoma, double valve resection of the lesion, uterine artery blockage