Abstract: Objective〖HTSS〗To analyze the influencing factors and the characteristics of different degrees of brain white matter injury in preterm infants.
〖WTHZ〗Methods〖HTSS〗126 cases of premature infants with brain white matter injury were selected as the observation group, and 88 cases of full-term normal infants were selected as the control group. Logistic regression analysis was used to determine the risk factors of brain white matter injury in preterm infants. Further analyze the clinical data of different degrees of brain white matter injury in the observation group, and explore the clinical characteristics of premature infants with different degrees of brain white matter injury.
〖WTHZ〗Results〖HTSS〗In the observation group, the fetal age, the proportion of cesarean section, the level of myocardial enzyme, C-reactive protein(CRP), albumin, the incidence of post natal infection and intrauterine distress were significantly higher than those in the control group(P＜0.05 or P＜0.01). Logistic regression analysis showed that low gestational age, high CRP, infection after birth, and intrauterine distress were independent risk factors for the occurrence of brain white matter injury in preterm infants. The incidence of infection, CRP and intrauterine distress increased with the severity of the disease(P＜0.05 or P＜0.01).
〖WTHZ〗Conclusion〖HTSS〗Postnatal infection, low gestational age, high CRP and intrauterine distress are the risk factors for the occurrence of brain white matter injury in preterm infants. With the aggravation of the disease, the incidence of postnatal infection, high CRP and intrauterine distress gradually increases. The incidence of brain white matter injury in preterm infants can be reduced by doing a good job of perinatal health care.

Key words: brain white matter injury, infant, premature； root cause analysis