Abstract: Objective  To observe the effects oxycodone with laryngeal mask anesthesia in elderly undergoing transurethral resection of the prostate. 
Methods  A total of 90 elderly with transurethral resection of the prostate underwent laryngeal mask general anesthesia were divided into three groups randomly: group fentanyl(group F), group sufentanil(group S),group oxycodone(group O). The induction of group F patients with fentanyl 1.5 μg/kg, group S sufentanil 0.15 mg/kg, group O oxycodone 0.15 mg/kg. Drugs of other induction and maintenance were the same. The data of mean arterial pressure(MAP) and heart rate(HR) were recorded at base line T0, induction completed T1, laryngeal mask placed 20 seconds(T2), operation started(T3), operation finished(T4), laryngeal mask pulled out(T5). The recovery time, dosage of drugs for maintenance, the Visual Analogue Score(VAS) and adverse reactions were recorded. 
Results  The dosages of remifentanil in group F were significantly higher than group S and group O(P＜0.05) .With the time extending, the MAP and HR of three groups all showed fluctuation, the MAP and HR in group F were significantly higher than group S and group O at T2(P＜0.05). There were significant differences in MAP and HR among time points of 3 groups(P＜0.05). The VAS scores of 3 groups increased with time extending, group F were higher than group S and group O, group S were higher than group O, there were significant differences in VAS scores among groups, time points and groups·time points of 3 groups(P＜0.05). 
Conclusion  Oxycodone 0.15 mg/kg was effectively applied to the elderly with transurethral resection of the prostate. It has more stable hemodynamic and an obvious advantage of postoperative analgesia, with no more adwerse reactions.

Key words: transurethral resection of prostate, oxycodone, general anesthesia