Abstract: Objective To study clinical value of magnetic resonance three-dimenstional time resolved imaging of contrast kinetics(3D-Tricks) combined with serum interleukin-6(IL-6) and antibody to heat shock protein 60(anti-HSP60) detection in the diagnosis of tubal infertility. 
Methods A total of 120 patients with suspected tubal infertility were examined by magnetic resonance 3D-Tricks technique and serum IL-6 and anti-HSP60 detection. It was divided into three methods: routine serum IL-6 anti-HSP60, magnetic resonance 3D-Tricks technique and combination of two detection methods, and the results of laparoscopic pathology were taken as the diagnostic gold standard. The sensitivity and specificity of magnetic resonance 3D-Tricks combined with serum IL-6 and anti-HSP60 detection were evaluated and the positive rate of IL-6 and anti-HSP60 were investigated in the diagnosis of tubal infertility. 
Results Eighty-four cases were diagnosed by laparoscopy in 120 cases, among of which the diagnostic coincidence rate of combined group(96.43%) was significantly higher than that of single group(80.00%), and the positive rates of serum anti-HSP60 and IL-6 in 84 cases of tubal infertility were significantly higher than that of non-tubal infertility, with statistical significance(P＜0.05).The sensitivity of parallel combined detection and diagnosis of magnetic resonance 3D-Tricks combined the detection of IL-6 anti-HSP60 was significantly higher than that of the single detection of 3D-Tricks and serum IL-6 and anti-HSP60(P＜0.05), the specificity of series combined detection was significantly higher than that of both alone(P＜0.05). The sensitivity of the series joint detection of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was significantly lower than that of parallel combined detection(P＜0.05), and the specificity was significantly higher than that of parallel combined detection . The area under the ROC curve of magnetic resonance 3D-Tricks technique combined the detection of serum IL-6 and anti-HSP60 was significantly higher than that of single detection(P＜0.05). 
Conclusion The combination of magnetic resonance 3D-Tricks and serum IL-6 and anti-HSP60 parallel detection can improve the sensitivity of the clinical diagnosis of tubal infertility, the series of tests can improve the specificity of the clinical diagnosis of tubal infertility, which is of great value for the early diagnosis of tubal infertility.

Key words: infertility,female, interleukin-6, anti-HSP60