Abstract: Objective  To explore the effect of personalized neuromuscular training on knee function, pain, stiffness and quality of life in patients with knee osteoarthritis(KOA). 
Methods  A total of 150 KOA patients treated in our hospital were selected and divided into observation group(n=75) and control group(n=75) by random number table method. The control group received resistance training, and the observation group received personalized neuromuscular training(including warm-up exercise, neuromuscular training, and cool-down exercise). The duration of treatment was 6 weeks. The total effective rate, pain and stiffness before and after treatment ［as assessed by the Western Ontario and McMaster University Osteoarthritis Index(WOMAC)］, 30 s chair-rising test, 40 m brisk walking test, the rate of analgesic use within 2 weeks before enrollment, serum tumor necrosis factor-α(TNF-α), interleukin-6(IL-6), interleukin-1β(IL-1β) levels, the rate of analgesic use within 2 weeks after treatment, knee function before and after treatment ［assessed by knee society score(KSS)］, quality of life ［measured by arthritis impact measurement scale 2-short form(AIMS2-SF)］. 
Results  The total effective rate of the observation group was higher than that of the control group(P＜0.05). The pain symptom score, stiffness symptom score, daily activity difficulty score, and total WOMAC score were decreased in both groups after treatment, as compared with those before treatment, and the scores were lower in the observation group than in the control group(P＜0.05). After treatment, 30 s chair-rising test, 40 m brisk walking test, and the rate of analgesic use within 2 weeks before enrollment were better than those before treatment, which were better in the observation group than in the control group(P＜0.05). After treatment, serum TNF-α, IL-6, and IL-1β levels of the two groups were lower than those before treatment, and the levels were lower in the observation group than in the control group(P＜0.05). The KSS scores and AIMS2-SF scores showed an increasing trend, which were higher in the observation group than in the control group, and there were significant differences between groups, time points and time points between groups(P＜0.05). 
Conclusion  Personalized neuromuscular training can improve the stability and coordination of the lower limbs, inhibit inflammation, improve the pain and stiffness of patients, and help improve the patient′s physical function, knee function and quality of life.

Key words: osteoarthritis, knee, personalized neuromuscular training, knee function