Abstract: Objective To study the relationship between the quantitative parameters of intravoxel incoherent motion(IVIM) imaging in small visual field and the pathological characteristics of prostate cancer(PC) and the value of combined diagnosis. 
Methods A total of 62 PC patients were selected as the observation group, and 62 patients with benign prostatic hyperplasia were selected as the control group. The general information and quantitative parameters of IVIM technology imaging ［pseudo diffusion coefficient(D*), perfusion fraction(f), diffusion coefficient(D), apparent diffusion coefficient(ADC)］ were compared between two groups. The receiver operating characteristic curve(ROC) was used to analyze the imaging quantitative parameters of IVIM technology and the value of the combined diagnosis of PC, and the imaging quantitative parameters of IVIM technology in patients with different pathological characteristics were compared. Spearman and Pearson were used for correlation analysis. 
Results The D and ADC of the observation group were lower than those of the control group(P＜0.05). There was no statistically significant difference in D* and f between two groups(P＞0.05). ROC analysis results showed that the AUC values of D and ADC in the diagnosis of PC were 0.800 and 0.773, respectively, and the AUC value of D combined with ADC in the diagnosis of PC was 0.865(P＜0.05). Logit(p) was used as an independent test variable, and the results showed that the AUC value of combined detection in the diagnosis was greater than that of single parameter detection alone(P＜0.05). No significant difference was found in D and ADC in patients with different 2016 editions of renal cancer WHO urology curriculum/International Society of Urological Pathology(ISUP) grade, D′Amico risk, tumor T stages, and Gleason scores(P＜0.05). There was no significant difference in D and ADC in patients with different tumor size and PSA level D(P＞0.05). D and ADC were negatively correlated with ISUP grade, Gleason score, D′Amico risk, and tumor T stages(P＜0.05). 
Conclusion Among the quantitative parameters of IVIM technology imaging, D and ADC have high sensitivity and specificity in diagnosing PC, and the parameter values are closely related to pathological characteristics. The combination of the two can not only further improve the diagnostic efficiency, but also provide a reference for clinical evaluation of pathological characteristics, and facilitate the formulation of treatment plans. 

Key words: prostatic neoplasms, intravoxel incoherent motion, diagnosis