Abstract: Objective To investigate the high-risk human papillomavirus(HR-HPV) infection in patients with different cervical lesions and the influencing factors of recurrence after cervical conization. 
Methods A total of 287 patients with cervical lesions were selected as the research subjects. According to the pathological examination results after cervical conization, they were divided into cervical inflammation group(n=34) and low-grade squamous intraepithelial lesions(LSIL) group(n=58), high-grade squamous intraepithelial lesion(HSIL) group(n=180), and cervical invasive carcinoma group(n=15). Human papillomavirus(HPV) infection rate, HPV single infection and multiple infections, and HR-HPV infection subtype distribution in the four groups were compared, and the recurrence rate of the HSIL group at 12 months after cervical conization was calculated. According to the recurrence, they were divided into recurrent patients and non-recurrent patients.The baseline data and HPV infection subtypes of patients with different recurrences were compared, and the influencing factors of recurrence after cervical conization in HSIL patients were analyzed. 
Results There were statistically significant differences in the total HRV infection rate and multiple HRV infection rates in the four groups(P＜0.05); the differences in the HRV 52, 58, 16, 18 infection rates in the four groups were statistically significant(P＜0.05).There were statistically significant differences in the postoperative resection margin status, menopausal status, multi-quadrant involvement, postoperative HR-HPV persistent infection, postoperative HR-HPV persistent infection subtypes, and cervical transformation types in the HSIL group with and without recurrence(P＜0.05).Postoperative resection margin positive status, menopausal status, multi-quadrant involvement, postoperative HR-HPV persistent infection, postoperative HPV 52 infection, HPV 58 infection, and cervical transformation type Ⅲ were the influencing factors for the recurrence of HSIL patients after cervical conization(P＜0.05). 
Conclusion There is a statistically significant difference in HPV 52 and 58 infection rates among patients with different cervical lesions, which is helpful to guide clinical evaluation of the efficacy and prognosis of cervical conization, provide scientific reference for the prevention and treatment of cervical cancer and its precancerous lesions and the search for more reasonable clinical diagnosis and treatment strategies.

Key words: cervical diseases, high-risk human papillomavirus, cervical conization