Abstract: Objective To study the effect of intravitreal injection of aflibercept combined with pan-retinal photocoagulation(PRP) in the treatment of diabetic macular edema(DME) induced by proliferative diabetic retinopathy(PDR). 
Methods Sixty patients(60 eyes) with PDR and DME were randomly divided into control group and experimental group. The former was treated with PRP alone, and the latter was treated with intravitreal injection of arbasip combined with PRP. At one month after treatment, the best corrected visual acuity(BCVA), central macular thickness(CMT), intraocular pressure and the incidence of complications were compared between  two groups. 
Results Before treatment, there was no significant difference in BCVA, intraocular pressure and CMT between two groups(P＞0.05). After treatment, BCVA in the experimental group was better than that in the control group, while intraocular pressure and CMT were lower than those in the control group(P＜0.05). Compared with those before treatment, BCVA increased while CMT decreased in both groups, and intraocular pressure increased in the control group(P＜0.05). The regression rates of neovascularization and non-perfusion area in the experimental group were better than those in the control group, and the incidence of complications in the experimental group was lower than that in the control group(P＜0.05). 
Conclusion Compared with PRP alone in the treatment of DME in the proliferative stage of DR, aflibercept combined with PRP can more effectively eliminate macular edema, better improve vision, and reduce the incidence of complications. Therefore, this combined treatment is a treatment method worthy of popularization.

Key words: diabetic retinopathy, aflibercept,  , pan-retinal photocoagulation