Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (2): 223-228.doi: 10.3969/j.issn.1007-3205.2022.02.020

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Therapeutic effect of Diacerein capsule combined with Imrecoxib tablet on patients with knee osteoarthritis and its effect on COX-2, WNT-3α and bone metabolism

  

  1. Department of Pharmacy, Sichuan Orthopaedic Hospital, Chengdu 610041, China
  • Online:2022-02-25 Published:2022-03-03

Abstract: Objective To investigate the effects of Diacerein capsule combined with Imrecoxib tablet on cyclooxygenase-2(COX-2), serumo sekretorinis glikoproteinase-3α(WNT-3α) and bone metabolism in patients with knee osteoarthritis(KOA). 
Methods A total of 160 patients with KOA admitted to our hospital were selected and divided into a single drug treatment group(n=80) and a combination treatment group(n=80) according to random number table method. Patients in the single drug treatment group were treated with Imrecoxib tablets, while patients in the combination treatment group were treated with Diacerein capsule combined with Imrecoxib tablets. Bone specific alkaline phosphatase(BALP) and tartrate-resistant acid phosphatase-5B(TRACP-5b), intereukin-1β(IL-1β), chitinase 3-like protein(YKL-40), and COX-2 levels were detected by enzyme-linked immunosorbent assay(ELISA). Tumor necrosis factor-α(TNF-α) levels were detected by turbidiometry, and the levels of osteocalcin(OC) and Wnt-3α were detected by radioimmunoassay. The therapeutic efficiency of the two groups was compared. 
Results After treatment, the levels of serum BALP and OC in the two groups were higher than those before treatment, while the levels of serum TRACP-5b, IL-1β, TNF-α, YKL-40, COX-2, and Wnt-3α were lower than those in the single drug treatment group. Compared with those in single drug treatment group, the serum BALP and OC levels in the combination treatment group increased, while the serum TRACP-5b, IL-1β, TNF-α, YKL-40, COX-2, and Wnt-3α levels decreased(P<0.05). After treatment, both the knee function score and visual analogue scale(VAS) score of both groups were lower than those before treatment, which were lower in the combination treatment group than in the single treatment treatment group(P<0.05). The therapeutic efficiency of the combination treatment group was higher than that of the single drug treatment group(P<0.05). 
Conclusion The treatment of KOA by Diacerein capsule combined with Imrecoxib tablets can effectively relieve pain, improve bone metabolism level, reduce inflammation and articular cartilage damage, and improve knee function.


Key words: osteoarthritis, knee, diacerein capsules, imrecoxib tablets