Abstract:

Objective  To explore the effects of siglitine combined with losartan potassium on angiogenesis-like protein 2(Angptl2) and glucose metabolism in diabetic patients with hypertension.

Methods  A total of 142 patients with diabetes mellitus and hypertension were selected as the subjects. According to the treatment methods, they were divided into siglitatin group(n=67, treated with siglitatin) and combination treatment group(n=75, treated with siglitatin combined with losartan potassium). The results of carotid ultrasound examination, blood pressure, vascular stiffness, glucose metabolism, renal function index and therapeutic effect were observed in the two groups, and the serum Angptl2 and vascular endothelial function was detected by enzyme linked immunosorbent assay(ELISA).

Results  In the combination treatment group, endometrial intermediate thickness(IMT), Crouse score, plaque detection rate, blood pressure, vascular stiffness, glucose metabolism, renal function indexes, and the levels of serum Angptl2 and vascular endothelial function were lower after treatment(P＜0.05). Total effective rate was higher in combination treatment group after treatment(P＜0.05). The total incidence of adverse reactions was slightly higher in combination treatment group than in the siglitine group, but there was no statistical difference between two groups(P＞0.05).

Conclusion  Siglitine and losartan potassium can effectively improve the clinical symptoms of patients with diabetes combined with hypertension, reduce the Angptl2 level, promote the normalization of sugar metabolism, and achieve good results with few adverse reactions. Therefore, it is worthy of promotion and popularization.

Key words: diabetes mellitus； hypertension； siglitine, losartan potassium