Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (4): 433-438.doi: 10.3969/j.issn.1007-3205.2022.04.013

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Study on the levels of C-reactive protein of first-degree relatives of schizophrenia patients and its related factors

  

  1. 1.Department of Psychosomatic Laboratory, Kailuan Mental Health Centre of Tangshan City, Hebei

    Province, Tangshan 063000, China; 2.The Fourth Inpatient Ward, Kailuan Mental Health Centre of

    Tangshan City, Hebei Province, Tangshan 063000, China; 3.Department of Neurosurgery,

    Kailuan Mental Health Centre of Tangshan City, Hebei Province, Tangshan 063000,

    China; 4.Department of Office, Kailuan Mental Health Centre of Tangshan City, Hebei Province, Tangshan 063000,  China

  • Online:2022-04-25 Published:2022-04-30

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Abstract:

Objective  To observe the expression of C-reactive protein(CRP) of first-degree relatives(FDR) of schizophrenia patients, and to analyze the related factors of changes of serum CRP.

Methods  In total, 100 schizophrenia patients who were hospitalized and 175 FDR were selected as research subjects. Patients with schizophrenia were taken as schizophrenia group, and the FDR served as FDR group. Another 200 healthy people who underwent physical examination in the hospital were selected as healthy control group. The serum CRP levels of all subjects were detected, and FDR was assessed by the symptom checklist(SCL-90), MATRICS consensus cognitive battery(MCCB) and positive and negative symptom scale(PANSS). The expressions of serum CRP levels were compared among the three groups, and the SCL-90 scores of FDR group and healthy control group were compared. The expression of CRP levels of FDR with different gender, age, mental health status, cognitive function, severity of symptoms were compared, and linear regression analysis was used to analyze the potential factors related to abnormal CRP levels in FDR.

Results  Among three groups, the serum CRP level of schizophrenia group was the highest, followed by FDR group and healthy control group, and the difference was statistically significant between groups(P＜0.05). The compulsive symptoms, somatization, interpersonal sensitivity, anxiety, depression, hostility, fear, paranoia, psychotic scores and total score in FDR group were higher than those in healthy control group, suggesting significant differences(P＜0.05). The results of linear regression analysis showed that poor mental health, poor cognitive impairment and moderate to severe symptoms might be related factors affecting serum CRP levels in FDR of patients with schizophrenia(P＜0.05).

Conclusion  The serum CRP level of FDR of patients with schizophrenia is highly expressed, which may be related to the poor mental health status, poor cognitive impairment, and combined symptoms of FDR with certain degree of schizophrenia. For people with a family history of schizophrenia treatment, if the schizophrenia patient is FDR, attention should be paid to the changes of expression of serum CRP levels. Serum CRP that is found to be abnormally high should be promptly intervened to reduce the incidence of schizophrenia.