Journal of Hebei Medical University ›› 2022, Vol. 43 ›› Issue (5): 517-520.doi: 10.3969/j.issn.1007-3205.2022.05.004

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Observation of the effect and adverse reactions of drug-coated balloon in the treatment of small coronary artery lesions in patients

  

  1. The First Department of Cardiovascular Medicine, East Branch of the Second Hospital of Hebei Medical University, Shijiazhuang 050031, China
  • Online:2022-05-25 Published:2022-05-30

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Abstract:

Objective  To explore the efficacy and safety of paclitaxel drug-eluting balloon in the treatment of small coronary artery lesions.

Methods  A total of 84 patients with small coronary artery lesions admitted to this hospital were selected as the subjects of this study. They were divided into the control group(n=42) and the research group(n=42) according to the numerical randomization method. The control group was given drug-eluting stent therapy, while the research group was given paclitaxel drug-eluting balloon therapy. The target angiography and adverse cardiovascular events at different time points were compared between two groups of patients with small coronary artery lesions.

Results  There were no significant differences in target lesion length, minimum lumen diameter, reference lumen diameter, and lumen stenosis before surgery and after pre-dilation of intravascular ultrasound between two groups(P＞0.05). Comparison of coronary angiography before and after surgery showed that the minimum lumen diameter and the degree of residual stenosis of two groups were improved after operation(P＜0.001). The degree of lumen stenosis in the research group at 6 months after operation was significantly lower than that in the control group(P＜0.05). The minimum lumen diameter  increased from (0.536±0.132) mm to (2.155±0.272) mm in the control group and from (0.517±0.127) mm to (2.212±0.264) mm in the research group(P＜0.05) at 6 months after operation, as compared with those before operation, and the difference was statistically significant. In addition, the degree of residual stenosis reduced from (78.50±4.87) % to (13.50±10.56) % in the control group and from (78.62±5.48) % to (8.93±8.43) % in the research group, and the difference was statistically significant(P＜0.05). At 12 months after operation, the incidence of adverse cardiovascular events in the research group was lower than that in the control group, and the difference was statistically significant(P＜0.05).

Conclusion  The use of paclitaxel drug-eluting balloon to treat small coronary artery lesions has significant effects on reducing late target vessel reconstruction and residual stenosis, which can effectively reduce adverse cardiovascular events and improve clinical safety.

Key words: coronary artery disease, drug-eluting stents, taxol, drug-eluting balloon