Abstract: Objective  To study the intra-day blood glucose variation of inpatients with type 2 diabetes mellitus (T2DM) between different regimens after insulin pump treatment. 
Methods  A total of 165 patients with T2DM were selected and given hypodermic insulin pump for hypoglycemic treatment. The pump was withdrawn after the blood glucose reached the standard. The patients were randomly divided into the detemir (Det)+aspart (Asp) group (control group) and the Asp30 group (experimental group). Blood glucose variation indexes including minimum blood glucose before removing the subcutaneous pump (bminGlu), standard deviation of blood glucose before removing the subcutaneous pump (bSDBG), postprandial glucose excursion before removing the subcutaneous pump (bPPGE), largest amplitude of glycemic excursions before removing the subcutaneous pump (bLAGE) and total insulin before removing the subcutaneous pump (bTins) on the day of pump with drawal were compared between two groups. The blood glucose variation indexes on the 4th day after insulin injection were compared between two groups, including minimum blood glucose after removing the subcutaneous pump (aminGlu), standard deviation of blood glucose after removing the subcutaneous pump (aSDBG), postprandial glucose excursion after removing the subcutaneous pump (aPPGE）, largest amplitude of glycemic excursions after removing the subcutaneous pump (aLAGE) and total insulin after removing the subcutaneous pump (aTins). 
Results  There was no significant difference in bminGlu, bSDBG, bPPGE, bLAGE, bTins, aminGlu, aSDBG, aPPGE, aLAGE and aTins (P＞0.05). 
Conclusion  For hospitalized patients with T2DM, both Asp30 injection twice a day and Asp+Det injection at meals could control blood glucose and reduce blood glucose fluctuation after insulin pump treatment. 

Key words: diabetes mellitus, type 2, insulin detemir, insulin aspart