Abstract: Objective To investigate the therapeutic effect and safety of cold light source phototherapy in full-term neonatal jaundice and its effect on oxidation and antioxidant system. 
Methods A total of 480 full-term infants with neonatal jaundice in our hospital were selected and divided into the control group (n=240) and the observation group (n=240) according to the random number table method. The control group was given ordinary blue light phototherapy, and the observation group was given cold light source phototherapy. The therapeutic effect, rehabilitation process, bilirubin indexes ［total serum bilirubin (TSB), conjugated bilirubin (DBIL), indirect bilirubin (IBIL)］, serum transferrin (TRF), oxidation and antioxidant system indicators ［malondialdehyde (MDA), superoxide dismutase (SOD), 8-hydroxy-2-deoxyguanosine (8-OHdG)］, children′s growth and development and adverse reactions were compared between two groups. 
Results The total effective rate of the observation group was 96.25%, which was higher than that (90.00%) of the control group (P＜0.05). Time to jaundice subsidence, time to bilirubin recovery, and length of hospitalization in the observation group were shorter than those in the control group (P＜0.05). Compared with the control group, the serum levels of DBIL,TSB and IBIL in the observation group were lower, and the TRF was higher (P＜0.05) at 3 d and 5 d after treatment. The serum levels of 8-OHdG and MDA in the observation group were lower than those in the control group, while the serum SOD level was higher than that in the control group at 3 d and 5 d after treatment (P＜0.05). The incidence of fever, rash, diarrhea, dehydration, irritability and crying in the observation group was lower than that in the control group (P＜0.05). Body weight, length and head circumference of the observation group were higher than those of the control group at 3 months after treatment (P＜0.05). 
Conclusion Cold light source phototherapy can improve the therapeutic effect of full-term neonatal jaundice, reduce the oxidative damage in the body, accelerate the metabolism of bilirubin in the body, and has few adverse reactions, which is helpful to promote the physical development of children. 

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