Abstract: Objective To investigate the effect of different cold-light phototherapy on the efficacy of neonatal jaundice and disease progression, and the occurrence of adverse reactions. 
Methods A total of 480 children with neonatal jaundice were selected and grouped according to the random number table method, with 240 cases in each group.The control group was given continuous cold-light phototherapy, and the observation group was given multiple intermittent cold-light phototherapy. At 1 week after treatment, the therapeutic effect, disease progression, jaundice index, serum total bilirubin (TBIL), total bile acid (TBA) levels, inflammatory factors ［C-reactive protein (CRP), interleukin (IL-2), interleukin-6 (IL-6)］ before and after treatment, auditory conduction pathway changes and adverse reactions were compared between two groups. 
Results The total effective rate in the observation group was 97.08% (233/240), which was higher than 90.00%(216/240) in the control group (P＜0.05). The time for meconium to turn yellow, the time for TBIL to return to normal, the time for jaundice to subside, and the length of hospitalization were shorter in the observation group than in the control group (P＜0.05). At 1 week after treatment, the jaundice index, serum TBIL and TBA levels in the observation group were lower than those in the control group (P＜0.05); The serum CRP, IL-2 and IL-6 levels in the observation group were lower than those in the control group at 1 week after treatment (P＜0.05). At 1 week after treatment, the interwave reaction threshold and latency Ⅰ value of the observation group were lower than those of the control group (P＜0.05); the incidence of adverse reactions in the observation group was 23.75% (57/240) lower than 41.67% (100/240) in the control group (P＜0.05). 
Conclusion Multiple intermittent cold-light phototherapy in neonatal jaundice is more effective than continuous cold-light phototherapy, which can effectively speed up the progression of the disease, improve symptoms and signs of high TBIL and jaundice, reduce inflammatory response, lower the threshold of auditory interwave response in children, and reduce the occurrence of adverse reactions. 

Key words: jaundice, neonatal, cold-lightphototherapy, total bilirubin