Abstract: Objective To compare the mid-term surgical effects of the two kinds of one-stage radical treatment of tetralogy of Fallot. 
Methods A retrospective analysis was performed on 101 patients with tetralogy of Fallot. According to the way of right ventricular outflow tract stenosis, the patients were divided into pulmonary valve transannular patch combined with autologous pericardium to make a single pulmonary artery valve group (group A, n=49) and simple trans-annular pulmonary artery patch group (group B, n=52). The clinical effects after one-stage radical treatment and at 5 years after surgery were compared between two groups. 
Results After one-stage radical treatment, the duration of ventilator assistance and length of intensive care unit (ICU) stay in group A were shorter than those in group B, and the degree of pulmonary valve regurgitation was better than that in group B (P＜0.05). At 5 years after follow-up, there were no significant differences in postoperative survival rate and surgical reintervention rate between two groups (P＞0.05). 
Conclusion One-stage radical treatment of tetralogy of Fallot with pulmonary valve transannular patch combined with autologous pericardium to make a single artificial pulmonary artery valve is better than that with transannular patch in shortening the duration of ventilator assistance and length of ICU stay, but there are no statistically significant differences in the 5-year survival rates after surgery and surgical re-intervention rates of the two groups. 

Key words: tetralogy of Fallot, transannular patch, artificial pulmonary valve