Abstract: Objective To explore the efficacy of sodium acetate Ringer′s solution and sodium lactate Ringer′s solution in patients with traumatic hemorrhagic shock (THS). 
Methods A total of 54 patients with THS were selected as the research subjects and randomly divided into an observation group (n=27) and a control group (n=27) using a random number table method.The observation group was resuscitated with sodium acetate Ringer′s solution, while the control group was resuscitated with sodium lactate Ringer′s solution. The resuscitation methods all involved restricted liquid resuscitation. Duration of resuscitation, total infusion volume, and mean arterial pressure (MAP) were compared between two groups. Peripheral venous blood was drawn before resuscitation, at 30 min after fluid resuscitation and at 1 h after resuscitation to detect the levels of interleukin (IL)-4, IL-6, IL-10 and tumor necrosis factor α (TNF-α) and lactic acid (Lac)value of arterial blood, peripheral platelet (PLT) count, plasma prothrombin time (PT), and fibrinogen (FIB) level. 
Results The duration of resuscitation and total infusion volume in the observation group were significantly shorter than those in the control group, and MAP was significantly lower than that in the control group (P＜0.05). The Lac levels in the observation group were gradually decreased compared to those in the control group, and there was a significant difference in the interaction between groups, time points, and time points between groups (P＜0.05). The PLT and FIB of the two groups showed a gradually decreasing trend, while the PT showed a gradually increasing trend; the difference between time points was statistically significant (P＜0.05), but there was no significant difference in the interaction between groups or time points between groups (P＞0.05). The levels of IL-4, IL-6, IL-10, and TNF-α in both groups showed a gradual upward trend; the levels of IL-4 and IL-10 in the observation group were higher, but the levels of IL-6 and TNF-α were lower, as compared with those in the control group, and there was a significant difference in the interaction between groups and time points (P＜0.05). There was no significant difference in the interaction between time points between groups (P＞0.05). 
Conclusion Early use of sodium acetate Ringer′s solution in patients with THS can better inhibit the expression of inflammatory factors in peripheral blood compared with sodium lactate Ringer′s solution, further reducing blood Lac levels. 

Key words: shock, traumatic, sodium acetate Ringer′s solution, sodium lactate Ringer′s solution