Abstract: Objective To explore the value of ultrasonic index combined with Framingham score in predicting cardiovascular risk in patients with ankylosing spondylitis (AS). 
Methods Retrospective research methods were used, and 120 patients with AS treated in our hospital were selected. During the follow-up period, 48 patients with cardiovascular involvement were selected as the observation group, and 72 patients without cardiovascular involvement were selected as the control group. The clinical data, carotid intima thickness, carotid femoral pulse wave velocity (PWV), Framingham score, bath ankylosing spondylitis disease activity index (BASDAI) score and bath ankylosing spondylitis function index (BASFI) score of the two groups were compared. 
Results The age and course of the patients in the observation group were greater or longer than those in the control group, and the long-term hormone treatment rate in the observation group was higher than that in the control group (P＜0.05). The carotid intima thickness, carotid femoral PWV, Framingham score, BASDAI score and BASFI score in the observation group were significantly higher than those in the control group (P＜0.05). The course of disease, long-term hormone treatment, carotid intima thickness, and Framingham score were the influencing factors of cardiovascular involvement in patients with AS (P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of this model in predicting cardiovascular involvement was 0.826 (95%CI：0.784-0.901, P＜0.05), and the sensitivity and specificity were 70.0% and 81.5% respectively. 
Conclusion The occurrence of cardiovascular involvement in patients with AS is affected by the course of disease, long-term hormone treatment and other factors. In the meantime, carotid intima thickness, Framingham score and other factors in combination have good value in predicting the occurrence of cardiovascular involvement.

Key words: spondylitis, ankylosing, ultrasonic index, Framingham score