Abstract: Objective To explore the risk factors of coagulation dysfunction caused by cefoperazone sodium and sulbactam sodium. 
 Methods A total of 100 patients treated with the third generation cephalosporin antibiotic (cefoperazone sodium and sulbactam sodium) were collected. Patients were divided into abnormal group (n=29) and normal group (n=71) according to presence of abnormal coagulation function. Gender, age, body temperature, pulse, treatment course, white cell count (WBC), albumin, urea nitrogen, total bilirubin (TBIL), procalcitonin (PCT), C-reactive protein (CRP), diet, drug dosage, and combined underlying diseases were compared between two groups. Multivariate Logistic regression analysis was used to identify the risk factors of coagulation dysfunction. The correlations of WBC, albumin, urea nitrogen, CRP, with PT and APTT were analyzed by Person coefficient. 
 Results There was no significant difference in gender, age, body temperature, pulse, treatment course, TBIL, PCT, CRP, combined hypertension and diabetes between two groups (P＞0.05). The levels of albumin in abnormal group were significantly lower than those in normal group, while the levels of WBC, urea nitrogen, CRP, diet ＜ 1 200 mL/d, and dosage ≥3 g/d were higher than those in normal group (P＜0.05). Receiver operating characteristic (ROC) analysis proved that WBC, albumin, urea nitrogen and CPR levels could be used to predict coagulation dysfunction of cefoperazone sodium and sulbactam sodium during anti-infection process, and the areas under the ROC curve were 0.913, 0.829, 0.920 and 0.847, respectively (P＜0.05). Multivariate Logistic regression analysis confirmed that diet ＜ 1 200 mL/d, dosage ≥3 g/d, WBC ＞ 11.385×109/L, albumin ＜ 28.815 g/L, urea nitrogen ＞ 14.199 μmol/L, CRP ＞ 17.629 mg/L were the risk factors for coagulation dysfunction (P＜0.05). Correlation analysis showed that WBC, urea nitrogen and CPR levels were positively correlated with PT and APTT, while albumin was negatively correlated with PT and APTT (P＜0.05). 
 Conclusion The coagulation dysfunction caused by cefoperazone sodium and sulbactam sodium in anti-infection process is affected by various factors, such as higher WBC, urea nitrogen, CPR level, lower albumin level, higher dosage, and less diet. The higher WBC, urea nitrogen and CPR levels and the lower albumin level, the worse the coagulation function of patients. 

Key words: Cefoperazone sodium and sulbactam sodium, blood coagulation disorders, influencing factor analysis