Journal of Hebei Medical University ›› 2024, Vol. 45 ›› Issue (2): 236-241.doi: 10.3969/j.issn.1007-3205.2024.02.020

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Effect of serum resistin on depression in elderly patients with diabetes

  

  1. 1.Geriatrics Department, People′s Hospital of Inner Mongolia Autonomous Region, Hohhot 010010, China; 
    2.Department of Endocrinology, People′s Hospital of Inner Mongolia Autonomous Region, 
    Hohhot 010010, China; 3.Department of Mental Health, People′s Hospital of  
    Inner Mongolia Autonomous Region, Hohhot 010010, China

  • Online:2024-02-25 Published:2024-02-06

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Abstract: Objective To explore the effect of serum resistin on depression in elderly patients with diabetes. 
Methods In this study, 114 elderly patients with diabetes were selected as the subjects. The Geriatric Depression Scale 15 (GDS-15) was used to assess the depression. The CDS-15 score>4 was regarded as depression, and the serum resistin level of elderly diabetic patients with depression was compared. The quartile of serum resistin level was divided into 4 groups to test the effect of serum resistin level on depression in elderly patients with diabetes. Receiver operating characteristic (ROC) curve was drawn to analyze the value of serum resistin in predicting depression in patients. 
Results Among 114 elderly patients with diabetes, 26 were accompanied by depression, with an incidence of 22.81%. The serum resistin levels in the depression group were significantly higher than those in the non-depression group (P＜0.05). There was a statistically significant difference in serum triglyceride (TG) levels among groups with different levels of serum resistin (P＜0.05). The binary correlation analysis showed that depression in elderly patients with diabetes was positively correlated with serum resistin level (P＜0.05). The results of bivariate Pearson correlation showed that the serum resistin level in elderly patients with diabetes was positively correlated with TG and HbA1c levels (P＜0.05). Logistic regression analysis showed that serum resistin, TG and glycosylated hemoglobin levels were the influencing factors of depression in elderly patients with diabetes (P＜0.05). The area under curve (AUC) of the serum resistin level in predicting depression in elderly diabetic patients at the time of enrollment was 0.808. 
Conclusion The level of serum resistin can affect the risk of depression in elderly patients with diabetes. The higher the level of serum resistin, the higher the risk of depression in patients with diabetes, which can be used as an auxiliary indicator to predict the risk of depression in patients with diabetes. 


Key words: diabetes mellitus, aged, depression, resistin