Abstract: Objective To evaluate the surgical effect of congenital heart disease (CHD) in infants and young children with low body weight (≤10 kg), and to summarize the clinical experience. 
Methods The clinical data of 1 382 infants and young children with CHD and low body weight (≤10 kg) in Department of Cardiac Surgery were retrospectively analyzed. There were 665 males and 717 females, and the age ranged from 6 days to 3 years, with a mean of (9.58±1.84) months; The average body weight was (8.82±1.13) kg. Of all patients, 1 305 patients underwent radical resection of heart malformations under general anesthesia, and 77 patients underwent palliative surgery. 
Results The operation was successful in the whole group, and 13 cases died after operation, accounting for 0.94%. The causes of death included low cardiac output syndrome in 7 cases, malignant arrhythmia in 1 case, hypoxemia in 5 cases (including severe pulmonary infection in 2 cases). 
Conclusion Surgical treatment is safe, feasible and valuable for CHD infants and youny children with low body weight, suggesting good clinical effect. However, it is necessary to correctly control the timing of the surgery, shorten the duration of operation, strictly manage the perioperative period, and improve the surgical efficacy.

Key words: heart diseases, infant, low birth weight, surgical procedures