Journal of Hebei Medical University ›› 2024, Vol. 45 ›› Issue (6): 632-637.doi: 10.3969/j.issn.1007-3205.2024.06.003

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The correlation between serum PGRN and SDF-1 levels and cognitive impairment in patients with acute cerebral infarction under the condition of collateral circulation establishment

  

  1. 1.Department of Laboratory Medicine, the First Affiliated Hospital of Xi′an Jiaotong University, 
    Shaanxi Province, Xi′an 710061, China; 2.Department of Laboratory Medicine, the Affiliated 
    Hospital of Xi′an Medical College, Shaanxi Province, Xi′an 710309, China; 3.Department of 
    Laboratory Medicine, the Second Affiliated Hospital of Air Force Military 
    Medical University, Shaanxi Province, Xi′an 710000, China

  • Online:2024-06-25 Published:2024-06-25

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Abstract: Objective To investigate the correlation between serum levels of progranulin(PGRN) and stromal derived factor-1 (SDF-1) and acute cerebral infarction (ACI) under the condition of collateral circulation establishment. 
Methods A total of 130 ACI patients were selected as the research subjects. According to the evaluation of the patient′s status of cerebral collateral circulation, they were divided into two groups: fine collateral circulation (FCC; n=72) group and poor collateral circulation (PCC; n=58) group. The levels of serum PGRN and SDF-1 were detected by enzyme-linked immunosorbent assay (ELISA). Cognitive function was assessed using the Montreal Cognitive Assessment Scale (MoCA). The correlation between changes in the above indicators and cognitive impairment after ACI was compared and analyzed. 
Results The SDF-1 level in the PCC group increased compared with the FCC group (t=2.705, P＜0.05), while the PGRN level decreased (t=5.747, P＜0.05). The MoCA score in the PCC group was lower than that in the FCC group (t=5.302, P＜0.05). There was a negative correlation between serum PGRN and SDF-1 levels in ACI patients (r=-0.289, P＜0.05). There was a positive correlation between PGRN level and MoCA score in ACI patients (r=0.203, P＜0.05), and a negative correlation between SDF-1 level and MoCA score (r=-0.204, P＜0.05). The area under the receiver operating characteristic (ROC) curve (AUC) of serum PGRN and SDF-1 levels detected alone and in combination for the diagnosis of cognitive impairment in ACI patients was 0.795 (95%CI: 0.709-0.888, P＜0.01), 0.727 (95%CI: 0.636-0.818, P＜0.01), and 0.805 (95%CI: 0.727-0.884, P＜0.01), respectively. The sensitivity and specificity of PGRN and SDF-1 detected alone and in combination for the diagnosis of cognitive impairment were 89.70% vs. 53.40%, 63.80% vs. 91.40%, and 96.60% vs. 51.70%, respectively. 
Conclusion Analyzing the correlation between serum PGRN and SDF-1 levels and cognitive impairment in patients with ACI under different conditions of collateral circulation can predict the occurrence of cognitive impairment and provide the oretical guidance for the selection of clinical intervention measures for cognitive impairment. 


Key words: cerebralinfarction, collateral circulation, cognitive impairment