Abstract: Objective To observe and explore the effects of ultra-pure dialysate combined with high flux dialysis on oxidative stress, microinflammatory state and calcium-phosphorus metabolism in patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (MHD). 
Methods Clinical data of 120 patients with ESRD undergoing MHD who were treated in our hospital were retrospectively analyzed, and the patients were divided into ultra-pure dialysate group (n=60) and non-ultra-pure dialysate group (n=60) according to different dialysis methods. The non-ultra-pure dialysate group received conventional dialysate, and the ultra-pure dialysate group received ultra-pure water + central liquid supply of concentrated A solution+ B powder cylinder configuration. All patients underwent high flux dialysis. Serum oxidative stress indicators ［malondialdehyde (MDA), glutathione peroxidase (GSH-px)］, microinflammatory state ［interleukin-6 (IL-6), interleukin-13 (IL-13), C-reactive protein (CRP), albumin (ALB), hemoglobin (Hb), hematocrit (HCT)］, renal function indicators ［blood urea nitrogen (BUN), serum creatinine (SCr), β2 microglobulin (β2-MG), estimated glomerular filtration rate (eGFR)］ and calcium-phosphorus metabolism were compared between the two groups after treatment. 
Results After treatment, the levels of MDA, IL-6, CRP, ALB, Hb, HCT and blood calcium in both groups were significantly increased (P＜0.05), while the levels of GSH-px, IL-13, BUN, SCr, β2-MG, eGFR, blood phosphorus and calcium-phosphorus product were significantly decreased (P＜0.05), and the above indicators except ALB and HCT were significantly different between ultra-pure dialysate group and non-ultra-pure dialysate group (P＜0.05).  
Conclusion Ultra-pure dialysate combined with high flux dialysis can effectively improve the body′s oxidative stress response and microinflammatory state, help stabilize the balance of calcium-phosphorus metabolism and delay the loss of residual kidney function in patients with ESRD undergoing MHD, and it is worthy of clinical promotion and application. 

Key words: renal failure, chronic, ultra-pure dialysate, high flux dialysis